نتایج جستجو برای: ctla4
تعداد نتایج: 1760 فیلتر نتایج به سال:
BACKGROUND Several polymorphisms of the CTLA4 gene have been associated with autoimmune diseases. The activation of induced cell death is the major event and caspase 3 represents the main protein for the apoptotic machinery, especially in lymphocytes. AIM To correlate CTLA4 polymorphisms with caspase 3 expression in peripheral blood mononuclear cells (PBMC) simulating in vitro the glucose eff...
BACKGROUND Immune system affects prognosis of various malignancies. Anti-immune pathways like PD-L1 and CTLA4 are used by the tumor to overcome immune system and they serve as immunotherapy targets. The immune microenvironment of head-and-neck squamous cell carcinoma (SCCHN) has not been sufficiently studied. PATIENTS AND METHODS 152 SCCHN were immunohistochemically studied for the expression...
Naive T cells require interleukin 4 (IL-4) to develop into IL-4-producing T cells and IL-4 blocks development of such cells into interferon gamma (IFN-gamma) producers. Prior studies in accessory cell-independent priming systems using antireceptor antibodies as agonists have demonstrated that IL-2 is also necessary for the development of IL-4-producing cells under these culture conditions. Here...
OBJECTIVES The aim of this study was to investigate the geographic distribution of β-globin gene mutations in different ethnic groups in Yunnan province. METHODS From 2004 to 2014, 1,441 subjects with hemoglobin disorders, identified by PCR-reverse dot blot and DNA sequencing, were studied according to ethnicity and geographic origin. Haplotypes were examined among 41 unrelated thalassemia ch...
objective: celiac disease (cd) is developed via autoimmune reactions against gluten which is mainly found in grains. although hla dqb1 locus is the most important genetic susceptibility to cd, some other variants such as a49g and g1359t of ctla4 and cd14 genes respectively have been proposed as cd predisposing genetic factors in many various studies. we aimed to assess possible roles of a49g an...
PURPOSE Cytotoxic T lymphocyte antigen 4 (CTLA4), a key negative regulator of T-cell activation, is targeted by the antibody tremelimumab to release potentially useful antitumor activity. EXPERIMENTAL DESIGN This phase II trial investigated tremelimumab as a second-line treatment for patients with metastatic gastric and esophageal adenocarcinomas. Tremelimumab was given every 3 months until s...
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