Introduction: In the present era, the rapid diagnosis of infectious disease is becoming a challenge to the medical field. At this setup, the most common infectious diseases are considered for rapid, accurate diagnosis. Salmonella is one of the most common needed infectious agents to be identified as early as possible. Aim: To identify a specific and sensitive technique for early diagnosis of en...

The d-amino acid content of Ishizuchi-kurocha, a post-fermented tea produced in Ehime, Japan, was measured. Ishizuchi-kurocha mainly contains d-glutamic and d-alanine, but it also small amount d-aspartic acid. Two types lactic bacteria, Lactiplantibacillus plantarum (L. plantarum) Levilactobacillus brevis brevis), are the main species involved fermentation during process. Therefore, acid-produc...

BACKGROUND & OBJECTIVES Malaria is a life-threatening disease caused by Plasmodium parasites. The life-cycle of Plasmodium species involves several stages both in mosquito and the vertebrate host. In the erythrocytic stage, Plasmodium resides inside the red blood cells (RBCs), where it meets most of its nutritional requirement by degrad- ing host's haemoglobin. L-arginine is required for growth...

In 1985, through co-culture using PBMC of patients with recurrent primary small change nephropathy (IMLNS) and normal rat glomerular, Garin found that 35sulfate absorption of glomerular was improved and proteinuria was induced. These suggested that the PBMC of patients with relapsed IMLNS may release a factor leading to this result [4] and the muddy pine can reduce 35sulfate absorption of glome...

abstract         background and objective: lactic acid bacteria are gram-positive, catalase-negative, nonsporulating, either rod- or coccus-shaped bacteria that have beneficial effects on their hosts by producing antimicrobial substances such as lactic acid, hydrogen peroxide, bacteriocins and biosurfactants. bacteriocins are antimicrobial peptides that are produced by bacteria and can inhibit ...

background and objectives : streptokinase is used clinically as an intravenous thrombolytic agent for the treatment of acute myocardial infarction and is commonly prepared from cultures of streptococcus equisimilis strain h46a. the objective of the present study was the production of streptokinase from strain h46a and purification by chemical reduction method. materials and methods: the rate of...

Introduction: Introduction: Molecular components within the microenvironment act upon cell growth, survival/apoptosis, and proliferation. Immune system cells respond to molecules produced by the tumor and released in the surrounding microenvironment, such as cytokines, chemokines, and growth factors. This study aimed to identify the effects of tumor environment on monocyte-macrophage cell linea...

The molecular mechanisms of assembly and budding of hepatitis C virus (HCV) remain poorly understood. The budding of several enveloped viruses requires an endosomal sorting complex required for transport (ESCRT), which is part of the cellular machinery used to form multivesicular bodies (MVBs). Here, we demonstrated that Hrs, an ESCRT-0 component, is critical for the budding of HCV through the ...

1. Leukocytosis- and lymphocytosis-stimulating activity was present in fluid cultures of B. pertussis. The activity was found primarily in the culture supernatant fluid. 2. The sequential changes in the leukocyte response were similar to those previously observed following injection of intact bacteria into mice. 3. Activity was destroyed by heat and was diminished, but not abolished, by prolong...

Abstract Objectives: We have shown that chimeric antigen receptor (CAR) T cells with T-cell intrinsic PD1 dominant negative (PD1DNR) prolong functional persistence. Herein, we further define and extrinsic mechanistic functions of PD1DNR. Methods: Human were retrovirally transduced mesothelin targeted, CD28 co-stimulated CARs– either M28z (M) or PD1DNR (MDNR). Cytotoxicity, proliferation, phenot...