ALTJHoUGH the Barcroft apparatus is used extensively for the study ofrespiration in biological fluids, we have found no published work in which the accuracy of the results obtained has been submitted to a critical examination. This is somewhat surprising when it is considered that the Barcroft apparatus is employed so frequently for comparative work where the interpretation is often founded on ...

The present study examined the development of anticipatory motor planning in an object manipulation task that has been used to successfully demonstrate motor planning in non-human primates (Weiss et al. in Psychol Sci 18:1063-1068, 2007). Seventy-five participants from four different age groups participated in a cup-manipulation task. One group was preschool children (average age of 5.1 years),...

BACKGROUND Challenges in the diagnosis and classification of cholangiocarcinoma have made it difficult to quantify the true incidence of this highly aggressive malignancy. METHODS We analyzed the Surveillance, Epidemiology, and End Results data to assess long-term trends in the age-standardized incidence of intrahepatic and extrahepatic cholangiocarcinoma between 1973 and 2012, correcting for...

3563 Background: Molecular tumor profile assays (MTP) may predict the primary site of origin in CUP, but the impact of site-specific therapy on outcomes is undefined. Accurate identification of CUP patients (pts) with a colorectal site of origin would be expected to improve treatment results by directing the use of colorectal cancer regimens rather than empiric CUP regimens. METHODS We identi...

Aims Patients’ advocates, regulators and doctors have the constant objective to make the best treatments quickly available to patients. Compassionate use programmes (CUP) as defined by the EU Regulation (EC) No 726/2004 article 83.2 are designed to provide early access before the marketing authorisation (MA) of a medicine. It is necessary to evaluate the achievements of the present legislations...

Cementless total hip replacement (THR) is rapidly being accepted as the surgery for arthritic diseases of the hip joint. The bone-ingrowth rate in porous-type cementless implants was about 90% over 10 years after surgery, showing that biological fixation of cementless THR was well maintained on both the stem and cup sides. As for the stress shielding of the femur operated using a distal fixatio...

1 Cross infection risk: Healthcare associated infection is defined as an infection that occurred in a patient in the healthcare setting in whom the infection was not present, or incubating, at the time of admission [1]. The World Health Organization reported in 2002 that the problem of nosocomial-acquired infection affects 1.4 million people worldwide. Annually, in the United Kingdom approximat...

extremes and produced a story which is vivid, factual and Convincing. The theme?that of the cause and course of alcoholism ln a personality of refinement?is handled with insight and knowledge, sympathy and toleration, and built up without either sentimentality or sensationalism. Events move quickly but carry conviction, the style is impersonal and the descriptions succinct. To sticklers, the us...

Mobile image intensifiers are more readily used to assess acetabular cup placement when performing a total hip arthroplasty through a direct anterior approach. However, patient positioning affects pelvic tilt and rotation, which in turn requires proper C-arm fluoroscopy adjustments for image interpretation. The authors provide insight into the interpretation of acetabular cup positioning based ...

Findings of scientists touching lifestyle issues or popular habits are often provokingly and controversially discussed. A behavior that is repeated over numerous years is likely to have profound implications on a person's life, and possibly on the society as a whole. while several customs are adopted region-ally—for example, ingestion of yerba mate in south America or of hot spices in Asia—drin...