\The skull seems broken as with some big weapon, but there's no weapon at all lying about, and the murderer would have found it awkward to carry it away, unless the weapon was to small to be noticed." \Perhaps the weapon was too big to be noticed," said the priest, with an odd little giggle. Gilder looked round at this wild remark, and rather sternly asked Brown what he meant. \Silly way of put...

Trichohepatoenteric syndrome (THES) is characterized by chronic diarrhea, dysmorphic facies and hair abnormalities. Hepatic involvement varies from no abnormality to cirrhosis and hemochromatosis. Recently, mutations in the tetratricopeptide repeat domain 37 (TTC37) gene were identified to cause THES. The c.2808G>A variation was suggested as a possible founder mutation among the South Asians. W...

This paper is a complement to the Tectonometamorphic Map of the Canadian Shield, and contains a brief description of the metamorphic history of Proterozoic orogenic belts and rock sequences in the Canadian Shield in Ontario, with a focus on rocks of the Southern and Grenville provinces. Metamorphism in the Southern Province has generally been attributed to the Penokean orogeny (~1879–1820 Ma), ...

OBJECTIVE Little is yet known about the interactions between body image, self-image, medication use and adherence to medication in people with SLE. Using a qualitative mode of enquiry, we sought to understand these experiences within a group of patients diagnosed with SLE. METHODS Fifteen participants (14 female, 1 male) with SLE took part in semi-structured interviews. Their ages ranged from...

Introduction: Steroid is commonly prescribed anti-inflammatory drug used in some acute conditions as well for prolong period different indications. This life saving has significant side effects. Patients with steroid hazards are frequently encountered our clinical practice which should be minimized. Methodology: It was an Observational, Descriptive, Cross-sectional study. Study October 2013 to ...

Chronic stress has been suggested to influence the pathogenesis of Alzheimer's disease (AD); however, the mechanism underlying this influence remains unknown. In this study, we created a triple transgenic mouse model that overexpresses corticotrophin-releasing factor (CRF) and human amyloid-β protein precursor (AβPP), to investigate whether increases in the expression of CRF can mimic the effec...

BACKGROUND There are few studies of the incidence and clinical characteristics of pituitary apoplexy (PA) in pituitary adenoma patients, and the findings have been inconsistent. OBJECTIVE The aim of the study was to retrospectively assess the incidence, clinical presentation, surgical management and postoperative complications of PA in pituitary adenoma patients. METHODS A database was spec...

Ectopic ACTH/CRH co-secreting tumors are a very rare cause of Cushing's syndrome and only a few cases have been reported in the literature. Differentiating between Cushing's disease and ectopic Cushing's syndrome may be particularly difficult if predominant ectopic CRH secretion leads to pituitary corticotroph hyperplasia that may mimic Cushing's disease during dynamic testing with both dexamet...

Endogenous Cushing's syndrome is an endocrine disease resulting from chronic exposure to excessive glucocorticoids produced in the adrenal cortex. Although the ultimate outcome remains uncertain, functional and morphological brain changes are not uncommon in patients with this syndrome, and generally persist even after resolution of hypercortisolemia. We present an adolescent patient with Cushi...

OBJECTIVE Mifepristone, a glucocorticoid receptor antagonist, improves clinical status in patients with Cushing's syndrome (CS). We examined the pattern, reliability and correlates of global clinical response (GCR) assessments during a 6-month clinical trial of mifepristone in CS. DESIGN Post hoc analysis of secondary end-point data from a 24-week multicentre, open-label trial of mifepristone...