1 CombinatoRx, Incorporated, Cambridge, MA, USA, 2 Bioinformatics and Biomedical Engineering, Boston University, Boston, MA, USA and 3 Department of Biological Sciences and Department of Chemistry, Fairchild Center, Columbia University, New York, NY, USA * Corresponding author. CombinatoRx, Incorporated, 245 First St, Cambridge, MA 02142, USA. Tel.: þ 1 617 301 7151; Fax: þ 1 617 301 7110; E-ma...

Stomach cancer carcinomatosis peritonitis (SCCP) is a recalcitrant disease. The goal of the present study was to establish an in vitro-in vivo-like imageable model of SCCP to develop cell-cycle-based therapeutics of SCCP. We established 3-D Gelfoam® histoculture and tumor-sphere models of SCCP. FUCCI-expressing MKN-45 stomach cancer cells were transferred to express the fluorescence ubiquinized...

During the Southern Great Plains experiment, the synthetic aperture radiometer, ESTAR, mapped L-band brightness temperature over a swath about 50 km wide and about 300 km long extending west from Oklahoma City to El Reno and north from the Little Washita River watershed to the Kansas border. ESTAR flew on the NASA P-3B Orion aircraft at an altitude of 7.6 km and maps were made on 7 days between...

During the first 36 months after its introduction to Jamaica, ERCP was performed with relatively high overall morbidity and poor therapeutic success. We sought to evaluate outcomes after eight years of experience with ERCP at a tertiary level hospital in Jamaica. All consecutive patients who had ERCP performed between March 1999 and March 2007 were identified from an operative log. Their hospit...

Hym-301 is a peptide that was discovered as part of a project aimed at isolating novel peptides from hydra. We have isolated and characterized the gene Hym-301, which encodes this peptide. In an adult, the gene is expressed in the ectoderm of the tentacle zone and hypostome, but not in the tentacles. It is also expressed in the developing head during bud formation and head regeneration. Treatme...

Currently available methods for detection of tumors in vivo such as X-ray, computed tomography, and ultrasonography are noninvasive and have been well studied; the images, however, are not specific for tumors. Direct optical imaging of tumor cells in vivo that can clearly distinguish them from surrounding normal tissues may be clinically useful. Here, we describe a new approach to visualizing t...

The monoclonal antibody Cat-301 was used to examine neurons in the cerebral cortex and dorsal thalamus of several mammalian species, including Old World monkeys, cats, bush babies, guinea pigs, and rats. In each species, subpopulations of cortical and thalamic neurons are stained along the surfaces of their somata and proximal dendrites. Cat-301-positive cortical neurons include specific groups...

Diabetic foot ulcerations could result in serious consequences such as amputations. The up-regulation of matrix metalloproteinases and down-regulation of TIMP1 were remarked as distinctive biological characteristics in the diabetic dermal fibroblast. The current study was performed in order to clarify the effect of high glucose on formation of diabetic dermal fibroblast cell. In addition, the e...