Hydroxocobalamin is a recently approved antidote for the treatment of cyanide poisoning. The case presented involves a young patient administered empiric hydroxocobalamin due to suspected cyanide overdose. Due to the development of acute kidney injury and severe metabolic derangement, emergent hemodialysis was initiated. Unfortunately, hemodialysis was confounded by a recurrent "blood leak" ala...

BACKGROUND Carbon monoxide (CO), a common cause of poisoning in human beings has also been implicated in the death of animals. Though there are multiple studies on CO poisoning and relevant lethal blood COHb concentrations in humans, there are no reliable reports of diagnostic lethal carboxyhemoglobin percentage of saturation (COHb%) in cats. Additionally, due to shared housing environments, ex...

Poisoned patients are managed by supportive measures and/or by the use of specific antidotes. Antidotes can offer significant advantages over supportive measures alone in many poisoned patients. The term ‘antidote’ is used to refer to any agent used to chelate the toxin, enhance its elimination, neutralize its effect, or ameliorate future complications, rather than just a pure pharmacological a...

In this report we describe experiments to investigate a simple virulence model in which Pseudomonas aeruginosa PAO1 rapidly paralyzes and kills the nematode Caenorhabditis elegans. Our results imply that hydrogen cyanide is the sole or primary toxic factor produced by P. aeruginosa that is responsible for killing of the nematode. Four lines of evidence support this conclusion. First, a transpos...

The cyanogen potentials of local wines (burukutu, pito,) and the effect pH (5.6-9.0) on samples was determined using cyanomethemoglobin complex method. A total 108 test were analyzed hydrogen cyanide content found to vary considerably from 0.0313±0.0052 mg/L 0.2444±0.0010 mg/L. pito have highest potential with mean concentration at 8.4 burukutu lowest 8.2. in this study (0.2444±0.0010 mg/L) is ...

This study aimed at evaluating the impact of seasons on nutritional status and dietary cassava-related cyanide exposure in Burhinyi Idjwi, two areas eastern Democratic Republic Congo, witnessing similarly high cassava-derived poisoning but differently affected by konzo malnutrition. Cyanide content cassava roots flour, urinary thiocyanate levels (uSCN) 54 subjects (40 from 14 aged 28.7 (12.1) y...