Low circulating IGF-I is associated with increased fracture risk. Conditional depletion of IGF-I produced in osteoblasts or osteocytes inhibits the bone anabolic effect of mechanical loading. Here, we determined the role of endocrine IGF-I for the osteogenic response to mechanical loading in young adult and old female mice with adult, liver-specific IGF-I inactivation (LI-IGF-I(-/-) mice, serum...

Medical devices, particularly endovascular stents, manufactured from superelastic Nitinol, a nearequiatomic alloy of Ni and Ti, are subjected to complex mixed-mode loading conditions in vivo, including axial tension and compression, radial compression, pulsatile, bending and torsion. Fatigue lifetime prediction methodologies for Nitinol, however, are invariably based on uniaxial loading and thu...

• Multiaxial fatigue models for notches are analysed. The geometry is an infinite plate with a circular hole. evolution of the predictions increasing hole radius not monotonic. This non-monotonic observed experimentally. work shows analysis several multiaxial notches: Navarro-Rios’ model, which analyses interaction between crack and its associated plastic zone material microstructural barriers,...

Abstract Under strong earthquakes, reinforced concrete (RC) walls in high-rise buildings, particularly wall piers that form part of a coupled or core system, may experience axial tension–flexure loading. In this study, detailed finite element model was developed VecTor2 to provide an effective tool for the further investigation seismic behaviour RC subjected tension and cyclic lateral The verif...

Cyclic loading tests were conducted for eight composite joints (five interior and three exterior joints) with steel reinforced recycled concrete (SRRC) columns beams under cyclic loading. The axial compression ratio coarse aggregate (RCA) replacement percentage considered as the main design parameters above joints. seismic behavior of frame studied by numerical simulation constitutive models (R...

This paper investigates the force transmission modes, mainly described by probability density distributions, in non-cohesive dry and cohesive wet granular materials by discrete element modeling. The critical state force transmission patterns are focused on with the contact model effect being analyzed. By shearing relatively dense and loose dry specimens to the critical state in the conventional...

In this paper, a theoretical formula is presented to predict the instantaneous folding force of the first fold creation in a square column under axial loading. Calculations are based on analysis of “Basic Folding Mechanism” introduced by Wierzbicki and Abramowicz. For this purpose, the sum of dissipated energy rate under bending around horizontal and inclined hinge lines and dissipated energy r...

an analytical nonlinear stress-strain model and a microscopic damage index for confined and unconfined concretes together with a macroscopic damage index for reinforced concrete (rc) structures under cyclic loading are proposed. in order to eliminate the problem of scale effect, an adjustable finite element computer program was generated to simulate rc structures subjected to cyclic loading. by...

In this study, experimental study on six RC columns with different slenderness ratios under axial rapid loading was conducted to investigate the axial compression behaviour of RC columns considering the effect of strain rates. The failure pattern of the specimens and the relations of axial loading versus the axial deformation were described. From the test results, the specimens under static and...