Adrenocorticotropic hormone (ACTH) inhibited replication in functional adrenal tumor cells with a concomitant stimulation of steroidogenesis and a characteristic change of morphology from a flattened to a spherical type. [(3)H]Thymidine incorporation into DNA was inhibited by about 50% 6 hours after ACTH treatment. Both cyclic AMP and dibutyryl cyclic AMP inhibited [(3)H]thymidine incorporation...

The studies reported here were undertaken to clarify the cellular mechanism of the hypothalamic tripeptide, thyrotropin-releasing hormone (TRH), in clonal, hormone-responsive GH pituitary cells and to assess the possibility of a role for cyclic AMP as a mediator of TRH action. We investigated patterns of protein phosphorylation by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and au...

In this paper we adress a new cyclic problem: finding periodic schedules for unitary resource constrained cyclic scheduling problem. Such resource constraints are characterized by k, the number of types of functional units employed and mx the maximal number of processors of the same type. The main problem is to cope with both precedence delays and resources which make the problem NP-complete in...

Segmentation in vertebrate embryos is controlled by a biochemical oscillator ('segmentation clock') intrinsic to the cells in the unsegmented presomitic mesoderm, and is manifested in cyclic transcription of genes involved in establishing somite polarity and boundaries. We show that the receptor protein tyrosine phosphatase psi (RPTPpsi) gene is essential for normal functioning of the somitogen...

As computer architectures transition towards exponentially increasing parallelism we are forced to adopt parallelism at a fundamental level in the design of machine learning algorithms. In this paper we focus on parallel graphical model inference. We demonstrate that the natural, synchronous parallelization of belief propagation is highly inefficient. By bounding the achievable parallel perform...

This paper examines the problem of locating large fault-free subcubes in multiuser hypercube systems. We analyze a new location strategy, the cyclic buddy system, and compare its performance to the buddy system, the gray-coded buddy system, and several variants of them. We show that the cyclic buddy system gives a striking improvement in expected fault tolerance over the above schemes and, sinc...

Treatment of Chinese hamster ovary cells in vitro with dibutyrl adenosine cyclic 3':5'-monophosphate converts the culture from one of compact, randomly oriented cells that grow in multilayers to a monolayer of elongated, fibroblast-like cells growing parallel to one another. Testosterone propionate, which has a similar though smaller effect at high concentrations and after prolonged incubation,...

The cyclic miniprotein Momordica cochinchinensis Trypsin Inhibitor II (MCoTI-II) (34 amino acids) is a potent trypsin inhibitor (TI) and a favored scaffold for drug design. We have cloned the corresponding genes and determined that each precursor protein contains a tandem series of cyclic TIs terminating with the more commonly known, and potentially ancestral, acyclic TI. Expression of the prec...

A number of phosphodiesterases which can hydrolyze ribonucleoside 2’, 3’-cyclic phosphates have been demonstrated in several biological materials (l-6). The preceding paper (7) presented evidence which strongly suggests the existence of a novel enzyme, designated temporarily as a cyclic phosphodiesterase, in the 78,000 x g supernatant of Escherichia coli B. At the same time a 3’-nucleotidase (E...

The asymmetric unit of the title compound, C(6)H(13)N(2)O(+)·C(8)H(7)O(2) (-)·0.5H(2)O, comprises two isonipecotamide cations, two phenyl-acetate anions and a water mol-ecule of solvation. The hydrogen-bonding environments for both sets of ion pairs are essentially identical with the piperidinium and amide 'ends' of each cation involved in lateral heteromolecular hydrogen-bonded cyclic N-H⋯O as...