نتایج جستجو برای: cyclin a2

تعداد نتایج: 48839  

Journal: :Journal of hematology & oncology 2017
Francesca Megiorni Giovanni Luca Gravina Simona Camero Simona Ceccarelli Andrea Del Fattore Vincenzo Desiderio Federica Papaccio Heather P McDowell Rajeev Shukla Antonio Pizzuti Filip Beirinckx Philippe Pujuguet Laurent Saniere Ellen Van der Aar Roberto Maggio Francesca De Felice Cinzia Marchese Carlo Dominici Vincenzo Tombolini Claudio Festuccia Francesco Marampon

BACKGROUND EPH (erythropoietin-producing hepatocellular) receptors are clinically relevant targets in several malignancies. This report describes the effects of GLPG1790, a new potent pan-EPH inhibitor, in human embryonal rhabdomyosarcoma (ERMS) cell lines. METHODS EPH-A2 and Ephrin-A1 mRNA expression was quantified by real-time PCR in 14 ERMS tumour samples and in normal skeletal muscle (NSM...

Journal: :acta medica iranica 0
hamed montazeri department of molecular biology, pasteur institute of iran, tehran, iran. saeid bouzari department of molecular biology, pasteur institute of iran, tehran, iran. kayhan azadmanesh department of virology, pasteur institute of iran, tehran, iran. seyed nasser ostad department of toxicology pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. mohammad hossein ghahremani department of toxicology-pharmacology, faculty of pharmacy, tehran university of medical sciences, tehran, iran. and department of molecular medicine, school of advanced technology in medicine, tehran university of medical sciences, tehran, iran.

cyclin e, her-2 and p53, are considered as major prognostic markers in breast cancer. as they are related in patho-clinical level, we aimed to check if they have any direct interaction on expression of each other. to study the effect of cyclin e on her-2 expression, cell lines stably overexpressing cyclin e or its low molecular weight (lmw) isoforms were generated. to understand the results of ...

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