There has been intense interest in the development of selective bioorthogonal reactions or "click" chemistry that can proceed in live animals. Until now however, most reactions still require vast surpluses of reactants because of steep temporal and spatial concentration gradients. Using computational modeling and design of pharmacokinetically optimized reactants, we have developed a predictable...

Described herein is interfacial bioorthogonal cross-linking, the use of bioorthogonal chemistry to create and pattern biomaterials through diffusion-controlled gelation at the liquid-gel interface. The basis is a rapid (k2 284000 M-1 s-1) reaction between strained trans-cyclooctene (TCO) and tetrazine (Tz) derivatives. Syringe delivery of Tz-functionalized hyaluronic acid (HA-Tz) to a bath of b...

The kinetics of cyclooctene epoxidation with H2O2 by micellar catalysis was studied. As catalyst, an ionic liquid (IL) containing the catalytically active tungstate anion used. IL forms micelles in aqueous phase. It is simply formed dissolving sodium and 1-octyl-3-methylimidazolium tetrafluoroborate [OMIM][BF4] H2O2. For catalysis, a power law kinetic model determined that takes critical micell...