نتایج جستجو برای: cyclooxygenase 1 and 2 enzyme
تعداد نتایج: 17525058 فیلتر نتایج به سال:
Prostaglandins are produced constitutively by many tissues in the body, including brain, gut, and kidney, and their synthesis increases at sites of inflammation. Cyclooxygenase (COX), the enzyme responsible for the initial rate-limiting metabolism of arachidonic acid to prostaglandin G2 and subsequently to prostaglandin H2, was first purified in ram seminal vesicles and was cloned in 1988 by De...
Enzyme cyclooxygenase (COX) is reported to play a significant role in neurodegeneration and may play a significant role in the pathogenesis of epilepsy. Bicuculline (4 mg/kg; ip), picrotoxin (8 mg/kg; ip) and electroshock (60 mA for 0.2 sec) significantly induced convulsions in male Laka mice. COX-inhibitors viz. nimesulide (2.5 mg/kg; ip) and rofecoxib (2 mg/kg, ip) administered 45 minutes pri...
Prostaglandin E(2) plays an important role in the maintenance of gastric mucosal integrity. The level of biologically active prostaglandin E(2) in the tissue is regulated by the balanced expression of its synthetic enzymes, such as cyclooxygenase, and its catabolic enzyme, 15-hydroxyprostaglandin dehydrogenase. We examined the effect of rebamipide, a mucoprotective drug, on prostaglandin E(2) p...
The initial step in the conversion of arachidonic acid to prostaglandins and related derivatives is catalyzed by the microsomal enzyme, cyclooxygenase. The ovine enzyme (from sheep vesicular glands) requires heme which is tightly bound as a prosthetic group (l-3). The bovine enzyme also requires heme (4) from which it is readily dissociated (5). In addition to free hematin, a variety of hemepro...
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