Under varying conditions the reaction of cysteamine hydrochloride (SHCH2CH2NH3)Cl with stoichiometric amounts of Cd and Pb salts in water gave [Cd2.5Cl5(SCH2CH2NH3)] (1), [Cd(SCH2CH2NH2)2] (2), [Pb2Cl(SCH2CH2NH2)3] (3) and [Pb2(SCH2CH2NH2)3](NO3)0.67(Cl)0.33 (4). Compound 1 is a molecular solid, one that contains a solid state-like core, but is nevertheless soluble in common organic solvents. T...

INTRODUCTION Cystinosis is a hereditary storage disease resulting in intracellular accumulation of cystine and crystal formation that causes deterioration of the function of many organs. The major clinical symptom is renal failure, which progresses and necessitates renal transplantation at the beginning of the second decade of life. Encephalopathy and distal myopathy are important neurological ...

Thienamycin derivatives (4) having a cyclic amidine moiety at the C-2 position were prepared. The susceptibility to renal dehydropeptidase-1 and the antimicrobial activity of these compounds were determined. Their structure-activity relationships are also discussed.

The effect of different extracts of leaves and fruits of Moringa oleifera Lam. (Moringaceae) on gastric and duodenal ulcers was evaluated by using different gastric ulcer models and cysteamine-induced duodenal ulcer method. The leaf extracts (500mg=kg, p.o.) of Moringa oleifera showed gastric ulcer healing effect in acetic acid–induced chronic gastric ulcers. The acetone extract and methanol ex...

Defective catabolite export from lysosomes results in lysosomal storage diseases in humans. Mutations in the cystine transporter gene CTNS cause cystinosis, but other lysosomal amino acid transporters are poorly characterized at the molecular level. Here, we identified the Caenorhabditis elegans lysosomal lysine/arginine transporter LAAT-1. Loss of laat-1 caused accumulation of lysine and argin...

Rats were kindled by intraperitoneal injection of pentylenetetrazol (PTZ) (30 mg/Kg) every 48 h. Once kindled, some of the animals received a single injection of cysteamine (200 mg/Kg). Somatostatin-like immunoreactivity (SLI) and 125 I-Tyr11-somatostatin binding were measured in the frontoparietal cortex and hippocampus of the two experimental groups and the control rats. After PTZ kindling th...

A depressed autophagy has previously been reported in cystic fibrosis patients with the common F508del-CFTR mutation. This report describes the synthesis and preliminary biological characterization of a novel series of autophagy activators involving fatty acid cysteamine conjugates. These molecular entities were synthesized by first covalently linking cysteamine to docosahexaenoic acid. The res...

Cystinosis is a rare autosomal recessive lysosomal storage disorder caused by mutations in the CTNS gene. Main dysfunction is a defective clearance of cystine from lysosomes that leads to accumulation of cystine crystals in every tissue of the body. There are three different forms: infantile nephropathic cystinosis, which is the most common form, juvenile nephropatic, and non-nephropathic cysti...

Interdigitated microelectrodes (IDEs) functionalized with a cysteamine (Cys) self-assembled monolayer (SAM) were used to fabricate a sensitive, disposable, impedimetric biosensor for prostate specific antigen (PSA) detection. PSA specific monoclonal antibody (anti-PSA) was covalently immobilized on cysteamine modified gold surface of IDEs, using N-ethyl-N’-(3-dimethylaminopropyl) carbodiimide a...