Abstract Gaining detailed insights into the role of host immune responses in viral clearance is critical for understanding COVID-19 pathogenesis and future treatment strategies. Although studies analyzing humoral against SARS-CoV-2 were available rather early during pandemic, cellular immunity came focus investigations just recently. For present work, we have adapted a protocol designed detecti...

Inflammatory changes within varicose veins can result in skin complications including venous leg ulcer (VLU). We have previously proposed that cytokines involved T cell activation are markers of disease and may be targets to attenuate progression. Here, we measured circulating from subjects with without ulcer. hypothesized associated interferon gamma (IFN-γ), IL-2, IL-12p70 would elevated vein ...

Abstract Purpose Physical activity and professional physical such as water polo (WP) sport, has numerous beneficial effects to fight metabolism-related disorders through several mechanisms, including the promotion of liver metabolic adaptations, modulation cytokine production. The aim this study was investigate different types on AMPK? ACC, two proteins involved in metabolism; therefore, we tre...

Abstract Multiplex ELISA assays are widely used in biomedical research for drug development and other therapeutic interventions. Monitoring of the immune responses subjects receiving candidate therapeutics is crucial mitigating adverse reactions necessary validation new candidates. Non-human primates (NHP) serve as a animal model novel due to similarities organ systems humans. To support this l...

BACKGROUND BCG is used widely as the sole licensed vaccine against tuberculosis, but it has variable efficacy and the reasons for this are still unclear. No reliable biomarkers to predict future protection against, or acquisition of, TB infection following immunisation have been identified. Lessons from BCG could be valuable in the development of effective tuberculosis vaccines. OBJECTIVES Wi...

an appropriate differentiation of distinct human cd4+ t cell subset is critical for manipulating these cells for using in immunity related diseases. despite various attempts to clarify the role of different factors involved in th17 differentiation, many crucial contradictions yet remained to be optimized. although it has been shown that the differentiation of in-vitro th17 cells culture conditi...

background: the alteration of th1 and th2 cytokine levels is the subject of controversy in pleural effusions caused by malignancy, a situation that favors a th2 immune response. objective: to examine the different levels of il-4 and il-10 (th2 cytokines), and il-2 and interferon-γ (ifn-γ) (th1 cytokines) in malignant and non-malignant pleural effusions. method: the cytokine levels in pleural fl...

introduction: interleukin-2 (il-2) as a t helper type 1 (th1) cytokine has an important role background and objective: interleukin-2 (il-2) as a t helper type 1 (th1) cytokine has an important role in activation, growth and differentiation of several immune cells. moreover il-2 is known as a pro-inflammatory and anti-tumoral cytokine. in addition deysregulation of il-2 in some diseases such as ...