Previously considered benign, Plasmodium vivax malaria infection is now increasingly being recognised as a cause of severe and complicated malaria1. We present a case of an 11-yr-old male child, who developed multiple organ dysfunction in the form of oliguric acute renal failure, hepatitis, gastrointestinal bleeding with shock, bacterial peritonitis along with severe anaemia and thrombo cytopen...

Infection-associated hemophagocytic syndrome is a life-threatening condition characterized by prolonged fever, hepatosplenomegaly, and cytopenia-most commonly, thrombocytopenia and anemia. It is characterized by proliferation and activation of benign histiocytes, causing dysfunction of various organs. Herein, we report on a 5-month-old boy whose clinical picture and laboratory findings were con...

Background Marrow failure and subsequent pancytopenia result from damage or suppression of pluripotent stem cells or progenitor cells, induced by drugs or viral infection. Physiologically, after the age of 65, bone marrow declines by an intrinsic reduction in cells with an increase of fat, displacing until replacement the hematologic tissue. Cytopenia may be severe and clinically significant in...

Introduction The term of macrophage activation syndrome (MAS) refers to a condition caused by excessive activation and expansion of T lymphocytes and macrophagic histiocytes that exhibit hemophagocytic activity. The expansion of these cells also leads to a massive systemic inflammatory response associated with pan cytopenia, liver dysfunction, and coagulopathy consistent by disseminated intrava...

We present the case of a 70-year-old woman who had a bone marrow examination performed to investigate marked thrombocytopenia in the context of a recent history of metastatic glucagonoma. Surprisingly this identified marked dysmegakaryopoiesis and fulfilled diagnostic criteria for refractory cytopenia with multilineage dysplasia, with a relatively uncommon associated cytogenetic lesion t(1;7). ...

We report here a patient with myelodysplastic syndromes (MDS), which was complicated with several autoimmune disorders and asymptomatic immunologic abnormalities. An 82-year-old woman with refractory anemia (RA) rapidly developed thrombocytopenia with the appearance of symptoms such as purpura, fatigue, anorexia, and weight loss. Furthermore, clinical examinations revealed that she also had Add...