perforin gene (prf1) mutations have been reported in 20-30% of patients with familial hemophagocytic lymphohistiocytosis (fhl), an immune disorder of infancy and early childhood. cytotoxic t and natural killer (nk) cell activities are remarkably reduced or ab-sent in fhl patients. we report the first cases of familial hemophagocytic lymphohistiocy-tosis in an iranian family with two siblings. e...

few studies have been conducted on the causative factors associated with the development of cancer. infection by high risk human papillomaviruses (hpvs) have been implicated as causative agents in a variety of cancers. hpv is capable of evading immune system and establishing persistent infections. prolonged infection and lesion maintenance are associated with higher risk of neoplastic progressi...

the medicinal plants have been used since ancient times and are still utilized by the majority of the population. hence, it is essential to investigate the cytotoxic and genotoxic effects of these plants. the aim of this study was to evaluate the toxic effects of fennel seeds decoctions, traditionally used in iran as an herbal remedy.  the cytotoxicity was tested in vitro using allium cepa l. r...

conclusions as l. crispatus and l. jensenni were significantly higher in bv infected women and the cytotoxic effect of l. crispatus on tumoral cervical cells was high, introduction of new probiotics seems necessary. results l. crispatus, l. gasseri, l. iners, l. jensenii, l. acidophilus and l. rhamnosus were the most frequently occurring species in vagina of healthy iranian women. l. crispatus ...

Hypersensitivity (HS) reactions to sulfonamides and sulfones continue to limit their use in human immunodeficiency virus (HIV)-infected individuals. In vitro cytotoxicity of hydroxylamine metabolites toward peripheral blood mononuclear cells (PBMCs) has been proposed as a marker for these HS reactions. To test the validity of this in vitro system, we determined the selective susceptibility of P...

Skin reactions at the infusion site are a common side effect of continuous subcutaneous insulin infusion therapy. We hypothesized that local skin complications are caused by components of commercial insulin formulations that contain phenol or m-cresol as excipients. The toxic potential of insulin solutions and the mechanisms leading to skin reactions were explored in cultured cells. The toxicit...

The pathogenetic mechanisms of progression chronic periodontitis accompanied with rheumatoid arthritis is confirmed by the common parts immune-inflammatory reactions. Damage to periodontal tissues indirectly made cytotoxic effects enzymes and their metabolites produced Porphyromonas gingivalis bacteria. Neutrophils contribute participate in its amplification recruiting T-helper cells 17 contrib...

background: mentha species are widely used in traditional medicine mostly as anti-flatulence. nowadays, their usage as flavor and preservative in food, cosmetic and pharmaceutical industries has been developed. moreover, cytotoxic effects of some mentha species have been reported. objective: in this study, cytotoxic properties of mentha piperita, m. spicata, m. aquatica, m. crispa, m. pulegium ...

the aim of this work was to see whether tamarin immunisation with recombinant vaccinia virus expressing epstein barr virus latent proteins could prime t cells which were, on activation, able to inhibit the outgrowth of epstein barr virus transformed cells in vitro. the vaccination appeared to be successful as all vaccinated tamarins developed vaccinia lesions. however, the vaccination protocol ...

background and objectives: iran owns a rich and prestigious heritage of medicinal herbs but the majority of these plants have not yet undergone chemical, pharmacological and toxicological studies. in the present study some species form northern parts of iran were evaluated for cytotoxicity. methods: sixteen medicinal plants were extracted with methanol and screened for their cytotoxic activitie...