Abstract: The development of time-critical Distributed Avionics Applications (DAAs) pushes beyond the limit of existing modeling methodologies to design dependable systems. Aerospace and industrial automation entail high-integrity applications where execution time is essential for dependability. This tempts us to use modeling technologies from one domain in another. The challenge is to demonstr...

Spontaneous activation enables the complement system to respond very rapidly to diverse threats. This activation is efficiently suppressed by complement factor H (CFH) on self-surfaces but not on foreign surfaces. The surface selectivity of CFH, a soluble protein containing 20 complement-control protein modules (CCPs 1-20), may be compromised by disease-linked mutations. However, which of the s...

BACKGROUND AND AIMS The risk of hepatocellular cancer (HCC) after sustained virological response (SVR) with direct-acting antivirals (DAA) is unclear. Our aim was to examine the risk and determinants of HCC in patients cured with DAA. METHODS We conducted a retrospective cohort study of hepatitis C virus patients who were treated with DAA in any of the 129 Veterans Health Administration hospi...

The cucumber (Cucumis sativus L.) is an economically important vegetable crop cultivated worldwide, including Vietnam. This study aims to determine the physiological ripening time of fruit establish a scientific basis for optimizing quality, harvest, and preservation. Changes in biochemical parameters during growth development cucumbers from 2 12 days after anthesis (DAA) were observed analyzed...

Direct-acting antiviral agents (DAAs) against hepatitis C virus (HCV) proteins open a whole new era for anti-HCV therapy, but DAA resistance associated variants (RAVs) could jeopardize the effectiveness of DAAs. We reported the global prevalence of DAA RAVs using published GenBank data. 58.7% of sequences (854/1455) harbored at least one dominant resistance variant and the highest RAV frequency...

Two important characteristics of the AAA should be apparent from the most casual appraisal: First, each branch-point-question calls on the clinician to apply his or her own experience and judgment, and second, the true role of the AAA is to help guide entrance into the American Society of Anesthesiologist’s Difficult Airway Algorithm (ASA-DAA). This calls attention to the misnomer of the ASA-DA...

D-Amino acid amidase (DAA) from Ochrobactrum anthropi SV3 catalyzes D-stereospecific hydrolysis of amino acid amides. DAA has attracted attention as a catalyst for the stereospecific production of D-amino acids, although the mechanism that drives the reaction has not been clear. Previously, the structure of DAA was classified into two types, a substrate-bound state with an ordered Omega loop, a...

Elymus sibiricus L. is an important forage grass widely distributed in Asia and is usually a dominant species on Tibetan Plateau alpine grasslands. Here, we used the seed development indices of 1000 seed weight, seed moisture content, and seed viability to compare the seed characteristics at 10, 20, 30, 40, 50, and 60 days after anthesis (DAA) in five populations of E. sibiricus growing in Gann...

Phosphorus (P) is translocated from vegetative tissues to developing seeds during senescence in annual crop plants, but the impact of this P mobilisation on photosynthesis and plant performance is poorly understood. This study investigated rice (Oryza sativa L.) flag leaf photosynthesis and P remobilisation in a hydroponic study where P was either supplied until maturity or withdrawn permanentl...