Abstract. A comprehensive 3D visco-elasto-plasto-damage constitutive model of concrete is proposed to analyze its behaviour under long-term and cyclic loadings. This combines the visco-elasticy plasticity theories together with damage mechanics. The work aims at providing an efficient capable predicting material behaviour, taking into account time-dependent effects mesoscale. visco-elastic part...

OBJECTIVES The authors utilize a model of activity-dependent neuronal plasticity to study the interplay between synaptogenesis, neuronal death, and neurogenesis on the resulting pattern of neuronal connectivity. DESIGN A mathematical model of neuronal network activity was employed, with plasticity instantiated by an activity-dependent rewiring rule. In particular, the authors modeled a neural...

Astrocytes regulate synaptic transmission and play a role in the formation of new memories, long-term potentiation (LTP), and functional synaptic plasticity. Specifically, astroglial release of glutamate, ATP, and cytokines likely alters the survivability and functioning of newly formed connections. Among these pathways, regulation of glutamate appears to be most directly related to the promoti...

Little is understood of how damaged white matter interacts with developmental plasticity. The authors propose that computational neuroscience methods are underused in this problem. In this article, they present a nondeterministic, in silico model of activity-dependent plasticity. Using this model, they compared the impact of neuronal cell loss or axonal dysfunction on the ability of the system ...

Our recent studies show that chronic oral nicotine partially protects against striatal damage in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated nonhuman primates. To identify the cellular changes associated with this protective action, we investigated the effects of nicotine treatment on stimulus-evoked dopamine release, dopamine turnover, and synaptic plasticity in striatum from l...

Many studies have shown strict relationship between neural plasticity and sleep deprivation in which long sleep loss can jeopardize the execution of neurocognitive and behavioral processes. Then, this fact is worse when one encounters with brain damage. Then, if sleep plays a role in modulating cortical plasticity, rehabilitative programs and techniques should be designed considering how sleep ...

Concrete is the main constituent material in many structures. The behavior of concrete is nonlinear and complex. Increasing use of computer based methods for designing and simulation have also increased the urge for the exact solution of the problems. This leads to difficulties in simulation and modeling of concrete structures. A good approach is to use the general purpose finite element softwa...

Many studies have shown strict relationship between neural plasticity and sleep deprivation in which long sleep loss can jeopardize the execution of neurocognitive and behavioral processes. Then, this fact is worse when one encounters with brain damage. Then, if sleep plays a role in modulating cortical plasticity, rehabilitative programs and techniques should be designed considering how sleep ...

The plasticity region of Helicobacter pylori is a large chromosomal segment including isolate-specific open reading frames with characteristics of pathogenicity islands. It remains unclear whether genes in the plasticity region play a role in the pathogenesis of gastric mucosal inflammation and gastroduodenal disease. Our aim was to assess the role of selected genes in the plasticity region in ...

fiber metal laminates (fmls) are new composite materials consisting of thin metal layers and high strength composite layers. arall (aramid aluminum laminate) is a family of the fml that consists of thin aluminum sheets along with kevlar/epoxy composite layers. this material has many advantages such as light weight, excellent corrosion, fatigue and impact resistance. since, arall is a new materi...