Genetic (G) and environmental (E) manipulations are known to alter behavioural outcomes in rodents, however many animal models of neuropsychiatric disorders only use a restricted selection of strain and housing conditions. The aim of this study was to examine GxE interactions comparing two outbred rat strains, which were housed in either standard or enriched cages. The strains selected were the...

Plasma glucose, insulin, and triglyceride concentration, blood pressure, and insulin action on isolated adipocytes were determined in weight-matched Sprague-Dawley, Dahl salt-resistant, and Dahl salt-sensitive rats. Blood pressure and plasma glucose concentrations were not significantly different in the three groups. However, Dahl salt-sensitive rats had significantly higher plasma insulin (39 ...

To investigate changes of MMP-9 in the rat spleen and hypoxia-induced microvascular basement membrane under high altitude hypoxia. Thirty male specific pathogen-free Sprague Dawley rats were randomly divided into control hypoxia groups, with 15 each group. The group placed Dingxi City, Gansu Province (2080 m above sea level) for 30 days. Rats raised a hypoxic environment Maduo County, Qinghai (...

The Dayak tribe in Kalimantan has long used bawang dayak as a traditional cure for various degenerative diseases. Previous research showed that bulb an active compound can inhibit the enzyme alpha-glucosidase, known alpha-glucosidase inhibitor (AGI). Compounds have such ability potential controlling blood glucose level diabetes mellitus. This aims to study effective dosage of aqueous extract an...

This study aimed to evaluate the effect of Hibiscus sabdariffa L. dried calyx ethanolic (HSE) extract on redox imbalance and glucose plasma vitamin B12 restriction Sprague-Dawley rats. The rat was fed a Vitamin Restriction Diet for 16 weeks treated with HSE as treatment group. One group diet not positive control group, another chow negative B12, MDA, SOD activity enzyme, levels were evaluated i...

The current study aimed to evaluate the chemical, phytochemical, and sensory properties; nutritional value; antioxidant properties resulting from incorporation of yogurt fortified with aqueous extract Hawthorn leaves in Sprague Dawley rats. results revealed that containing exhibited no significant differences terms its protein, fat, ash contents compared control samples. Moreover, highest total...

Alcoholism is a frequent comorbidity following mild traumatic brain injury (mTBI), even in patients without a previous history of alcohol dependence. Despite this correlational relationship, the extent to which the neurological effects of mTBI contribute to the development of alcoholism is unknown. In this study, we used a rodent blast exposure model to investigate the relationship between mTBI...

Purpose: To determine the effect of sevoflurane (SE) on neuronal apoptosis, and mechanism involved.Methods: Sixty healthy male Sprague-Dawley rats were assigned to control, model SE groups. Sham surgery was performed in control group, while middle cerebral artery infarction (MCAO) established group. The expression HO-1 mRNA determined by quantitative real-time polymerase chain reaction (qRT-PCR...

Lignosus rhinocerotis (Cooke) Ryvarden (LR) or tiger milk mushroom has traditionally been used in Malaysia due to its abundant medicinal properties. The potential effects of LR on the male and female fertility teratogenicity were investigated rats. Male Sprague Dawley (10 rats/group) orally administered with 0, 250, 500 1000 mg/kg/day extract for 30 consecutive days. Female (5 received same tre...

Mitochondrial dysfunction is common in the brain with age. Prevention of mitochondrial at an early age may protect against neurodegeneration later life. Tocotrienol-rich fraction (TRF) has been reported to be neuroprotective old rats, but its effect remains unknown for middle-aged animals. This study aimed determine TRF on activities respiratory chain complexes hippocampus rats. Male Sprague Da...