OBJECTIVES This study sought to define contemporary trends in permanent pacemaker use by analyzing a large national database. BACKGROUND The Medicare National Coverage Determination for permanent pacemaker, which emphasized single-chamber pacing, has not changed significantly since 1985. We sought to define contemporary trends in permanent pacemaker use by analyzing a large national database....

BACKGROUND The increasing availability of generic drugs (GD) resulted in a remarkable reduction in treatment costs that allowed a better access to health care.The aim of this study is to evaluate the share of anti-asthmatic generic drugs during the period 1999-2010 in Morocco and to look at the factors influencing generic development. METHODS In this study, we used Moroccan sales data from IM...


 As a result of the study core material 540 thin sections from boreholes northern marginal part and paraxial Dnieper-Donetsk Depression (DDD), complex fossil red calcareous algae including 14 species 7 genera, as well 2 belonging to genera identified for first time Visean deposits DDD has been discovered. The studied carbonate represent Hlybokynskyi, Sukhynskyi, Stylskyi, Donetskyi lower ...

Hipertensi adalahckondisi dimanactekanancdarah tinggi (sistolik>140cmmHg ataucdiastolik>90 mmHg) yang menetap. Hipertensictermasuk salah satu penyakit kronis membutuhkancpengobatan jangkacpanjang. Pasienchipertensi mengikuti Program RujukcBalik memerlukancpengobatan jangka panjangcsehingga perlunya dilakukancevaluasi. Oleh karena itu penelitian ini dilakukan untuk mengetahui konsumsi obat...

The purpose of this study was to investigate the clinical, laboratory, and pathologic characteristics of dense deposit disease (DDD) in Korean children and to determine whether these characteristics differ between Korean and American children with DDD. In 2010, we sent a structured protocol about DDD to pediatric nephrologists throughout Korea. The data collected were compared with previously p...

INTRODUCTION Nonpharmacological treatment of patients with hypertrophic obstructive cardiomyopathy (HOCM) comprises surgical myectomy (SME), alcohol septal ablation (ASA), and dual-chamber (DDD) pacing. The aim of the study was to compare the long-term effect of DDD pacing and ASA in symptomatic HOCM patients. PATIENTS AND METHODS We evaluated retrospective data from three cardiocenters; ther...

BACKGROUND AND OBJECTIVES This study was designed to investigate the causes of alternative pathway dysregulation in a cohort of patients with dense deposit disease (DDD). DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS Thirty-two patients with biopsy-proven DDD underwent screening for C3 nephritic factors (C3Nefs), factor H autoantibodies (FHAAs), factor B autoantibodies (FBAAs), and genetic va...

BACKGROUND Drug costs increasingly pose a burden upon the otherwise inadequate health care resources and rational drug utilization is an important segment of every national health policy. Optimal patient care should be the goal of rational pharmacotherapy, whereby the economic burden of treatment is just one of the elements to be considered on choosing appropriate therapy.The aim of this study ...

Trypanosoma brucei N-myristoyltransferase (TbNMT) is an attractive therapeutic target for the treatment of human African trypanosomiasis. Pyrazole sulfonamide (DDD85646), a potent inhibitor of TbNMT, has been identified in previous studies; however, poor central nervous system exposure restricts its use to the haemolymphatic form (stage 1) of the disease. In order to identify new chemical matte...

aim: the increasing prevalence of antibiotic-resistant bacteria is a major health-care problem worldwide. who recommends did (daily defined dose/ 100 inhabitant /day) as a standard tool for measurement of antibiotic consumption. since there was not any information regarding the antibiotics usage pattern in the north of iran, the aim of this study was determine this in our centre.method: this cr...