Dead-end elimination (DEE) is a powerful theorem for selecting optimal protein side-chain orientations from a large set of discrete conformations. The present work describes a new approach to dead-end elimination that effectively splits conformational space into partitions to more efficiently eliminate dead-ending rotamers. Split DEE makes it possible to complete protein design calculations tha...

Innovation is typically a trial-and-error process. While some research paths lead to the innovation sought, others result in dead ends. Because firms benefit from their competitors working in the wrong direction, they do not reveal their negative findings. Hence, time and resources are wasted on dead-end projects. We offer a model to study this prevalent problem and characterize the equilibrium...

It was suggested more than 30 yrs ago that inhibition of the clotting cascade by natural anticoagulants could decrease the high mortality observed in patients suffering from severe sepsis and septic shock. Unfortunately, this therapeutic "paradigm" has led to a dead end, illustrated by the failure of all randomized trials and the recent withdrawal of recombinant activated protein C. Should we n...

Hyponatremia is a clinically relevant disorder. Ten to twenty per cent of patients in hospitals are affected by it. Hyponatremia is found to occur in almost every clinical department. Recently, vasopressin antagonists have been licensed to treat hyponatremia of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). They provide physicians with the first specific and effective the...

Agent planning programs are finite-state programs, possibly containing loops, whose atomic instructions consist of a guard, a maintenance goal, and an achievement goal, which act as precondition-invariance-postcondition assertions in program specification. The execution of such programs requires generating plans that meet the goals specified in the atomic instructions, while respecting the prog...

The primary goal of relational databases is to provide e cient query processing on sets of tuples and thereafter, query evaluation and optimization strategies are a key issue in database implementation. Producing universally fast execution plans remains a challenging task since the underlying relational model has a significant impact on algebraic definition of the operators, thereby on their im...

dead yeast cells are an abundant residue of the brazilian ethanol industry and the industries still don’t have a proper or desirable destiny for all these cells, which means tons of vitamins and proteins that have not a major end. in the other hand, heavy metal residues are a problem, especially for leather industry, where brazil is also a great producer. in this work, dead yeast cells were us...

PURPOSE To identify the specific cognitive domains associated with passive suicidal ideation (e.g. thoughts of being better off dead). METHODS A cross sectional, national based study of 1,712 individuals over the age of 50. Outcome measure, passive suicidal ideation, was evaluated by the question, 'in the past month, have you felt that you would rather be dead?', taken from the Euro-D. Cognit...

Alcoholic hepatitis (AH) is a clinical syndrome characterized by jaundice and liver failure that develops in subjects with chronic and active alcohol abuse [1]. The shortterm mortality in patients with severe disease, as defined by the Maddrey’s discriminant function, exceeds 30% [2]. Up to now, only two drugs, prednisolone and pentoxifylline, have shown some efficacy for the treatment of this ...