Introduction: Infections are one of the main causes of death during childhood. Epidemiologic studies in Iran showed that the incidence of neonatal sepsis was 1.8% in 1995. Moreover, the incidence of neonatal meningitis is 0.2 to 0.4 in per 1,000 live births. The aim of this study was to determine the necessity of lumbar puncture (LP) in early neonatal sepsis. Methods: In a retrospective study, ...

remained unchanged for over a decade, and early recognition continues to be the most crucial factor in survival outcome. Early accurate diagnosis of infection organ dysfunction remains problematic, as evidenced by numerous interventional trials that have not resulted improved outcomes. These failures are partly because belated intervention, when patient developed multiple-organ failure therapeu...

conclusions in the present study, we identified a key gene rps16 and a significant module involved in ribosome biogenesis in eukaryotes that were related to neonatal sepsis, which might be potential biomarkers for early detection and therapy for neonatal sepsis. background the exact interacting factor that response to the infection for neonatal sepsis is still needed to urgently to be disclosed...

Background: The significant improvement of immediate and long-term functional results treating patients is the fundamental problem modern medical science. A deep understanding pathogenesis key point in creating management strategy for with various diseases. Information about mechanisms origin development purulent-inflammatory diseases sepsis essential finding effective ways to prevent treat the...

Abstract Sepsis is defined as a life-threatening organ dysfunction, which caused by dysregulated host response to infection. The composition of the intestinal microbiota significantly different between patients with sepsis and healthy individuals. Intestinal microbial imbalance plays an important role in occurrence development sepsis. Our review mainly introduces mechanism involvement sepsis, e...

In this article, we propose a transfer learning method for deep neural networks (DNNs). Deep learning has been widely used in many applications. However, applying deep learning is problematic when a large amount of training data are not available. One of the conventional methods for solving this problem is transfer learning for DNNs. In the field of image recognition, state-of-the-art transfer ...

Background Late onset sepsis is a frequent complication of prematurity, associated with increased mortality and morbidity. Probiotics may prevent late onset sepsis in premature infants. The aim of this study was to determine prophylactic effect of oral probiotics in prevention of late onset sepsis of very preterm infants. Materials and Methods This study was a randomized, double blinded, placeb...

Background: Bacterial sepsis is highly prevalent among premature infants. Amikacin is an antibiotic widely recommended for the treatment of neonatal sepsis, one of the consequences of which might be nephrotoxicity. The present study aimed to compare the efficacy and nephrotoxicity of multiple daily dosing (MDD) and once-daily dosing (ODD) of amikacin in preterm infants suspected of sepsis. Met...