Chronic psychological and social stress can cause psychiatric disorders in humans. In this study, we analyzed the mitogen-activated protein kinase (MAPK) cascade in the hippocampus of chronically socially defeated rats. The rats that were subjected to social defeat every day for 5 weeks showed physiological and behavioral changes, including a reduced rate of weight gain, enlarged adrenal glands...

The aim of the study was to assess the effect of basic technical-tactical elements, i.e. specific motor abilities, on performance in beach volleyball, with special reference to differences between the old and new official rules. Analysis of variance for 6 variables of technical-tactical elements between the winning and defeated teams included a sample of 129 sets played according to the old off...

Human depression is associated with cognitive deficits. It is critical to have valid animal models in order to investigate mechanisms and treatment strategies for these associated conditions. The goal of this study was to determine the association of cognitive dysfunction with depression-like behaviour in an animal model of depression and investigate the neural circuits underlying the behaviour...

Argument-based formalisms are gaining popularity as models of nonmonotonic reasoning. Central in such formalisms is a notion of argument. Arguments are formal reconstructions of how a conclusion is supported. Generally, an argument is defeasible. This means that an argument supporting a conclusion does not always justify its conclusion: the argument can be defeated. Whether a conclusion support...

This article provides an overview of the clinical evidence of interactions between herbal and conventional medicines. Herbs involved in drug interactions--or that have been evaluated in pharmacokinetic trials--are discussed in this review. While many of the interactions reported are of limited clinical significance and many herbal products (e.g. black cohosh, saw palmetto, echinacea, hawthorn a...

BACKGROUND There has been recent interest in the possibility that epigenetic mechanisms might contribute to the transgenerational transmission of stress-induced vulnerability. Here, we focused on possible paternal transmission with the social defeat stress paradigm. METHODS Adult male mice exposed to chronic social defeat stress or control nondefeated mice were bred with normal female mice, a...

Intraspecific coalitional aggression between groups of individuals is a widespread trait in the animal world. It occurs in invertebrates and vertebrates, and is prevalent in humans. What are the conditions under which coalitional aggression evolves in natural populations? In this article, I develop a mathematical model delineating conditions where natural selection can favor the coevolution of ...