Multiscale modeling of collagen fibril is carried out by incorporating the material properties of collagen obtained from steered molecular dynamics into the finite element model of collagen fibril with inclusion of crosslinks. The results indicate that the nonbonded interactions between collagen and mineral contribute to the significant enhancement of the elastic modulus of collagen fibril at a...

The atomic force microscopy (AFM) has been widely used to measure the mechanical properties of biological cells through indentations. In most of existing studies, the cell is supposed to be linear elastic within the small strain regime when analyzing the AFM indentation data. However, in experimental situations, the roles of large deformation and surface tension of cells should be taken into co...

In order to image the shear modulus in soft tissue, for medical diagnosis, given one component of measured displacements as a function of time on an imaging plane, two related direct finite element-based inversion algorithms are presented. One algorithm is based on the governing equations expressed in the frequency domain, and the other is in the time domain. The algorithms consider the complet...

Indentation testing is a widely used approach to evaluate mechanical characteristics of soft tissues quantitatively. Young's modulus of soft tissue can be calculated from the force-deformation data with known tissue thickness and Poisson's ratio using Hayes' equation. Our group previously developed a noncontact indentation system using a water jet as a soft indenter as well as the coupling medi...

Estimation and modeling of soft tissue deformation during cutting is important for developing a reality based haptic interaction model for surgical training and simulation. In this paper, we are interested in understanding the effect of parameter changes, such as the cutting speed and the angle of cutting, to develop a predictive model that is self consistent with the experimental observations....

The purpose of this study was to evaluate the dynamic viscoelastic properties of experimental silicone soft lining materials, Silastic MDX 4-4210 reinforced with silica fillers. Storage modulus (E'), loss modulus (E") and damping factor (tan delta) were determined using a dynamic mechanical analyzer under a deformation strain level of 0.27% at test frequency and a temperature range of 1 Hz and ...

+Fan, ZF; *Smith, PA, +Harris,GF; [email protected] +Orthopaedic & Rehabilitation Engineering Center (OREC) Marquette University/Medical College of Wisconsin, Milwaukee, WI *Shriners Hospital for Children, Chicago, IL Introduction: Nanoindentation was used to characterize the intrinsic mechanical properties of bone tissue from eight (8) children with type III Osteogenesis Imperfecta (OI...

One-dimensional "sonic vacuum" type phononic crystals were assembled from a chain of polytetrafluoroethylene (PTFE,Teflon) spheres with different diameters in a Teflon holder. It was demonstrated that this polymer-based sonic vacuum, with exceptionally low elastic modulus of particles, supports propagation of strongly nonlinear solitary waves with a very low speed. These solitary waves can be d...

Values of site factors in numerical simulation can have profound effects on the calculation accuracy. In order to fully understand the performance of rigid-pile composite foundation in tall buildings, this article set up an overall FEA model of a 25-storey frame-tube structure by considering the interaction of superstructure, foundation and ground. Thereafter, a detailed parametric study was pe...

In the present study, the combination of lattice Boltzmann and immersed boundary methods is used to simulate the motion and deformation of a flexible body. Deformation of the body is studied in microchannel with stenosis and the effect of the flexibility changes on its deformation is investigated. The obtained results in the present manuscript show that by increasing the elasticity modulus, the...