The intra-osseous pressure, PO2, and PCO2 were measured in 32 hips (21 patients) which were painful but showed no severe degenerative changes. Pre-operative scintigraphy and radiography was performed in all patients. Thirteen hips showed early osteoarthritis, eight had early osteonecrosis, and 11 had no changes. Core biopsies were performed and the bone was examined histologically and graded fo...

Background: A large proportion of patients presenting with lumbar disc disease are opium addicts in our region. It was, therefore, hypothesized that morphine might affect the intervertebral disc. We investigated the histological findings of morphine dependency on intervertebral discs in rat. Methods: Forty NMRI adult male rats (230-250 g) placed on ordinary diet and received aqueous solution of...

Bluetongue virus can infect all ruminants, although clinical disease in endemic regions is mainly associated with certain breeds of sheep, while cattle remain subclinically infected. The severity of disease is influenced by factors such as the virulence of the bluetongue strain, the livestock breed and individual susceptibility. Disease caused by the BTV-8 strain implicated in the recent outbre...

Background: Cervical spondylosis is a degenerative process involving changes in soft tissue and bone of intervertebral discs. Objective: To evaluate wrestling induced cervical spondylosis. Methods: 83 male wrestlers with the age range of 15 to 55 were randomly studied against 79 non-wrestlers of the same age. Clinical and radiological assessments were carried out and recorded in both groups. Wr...

In the present study we examined the effects of menadione, a redox cycling agent, on structural changes of human osteosarcoma line 143B cells. It has been previously reported that menadione can cause necrotic or apoptotic cell death in a concentration- depending manner. In our experimental model, cells were treated with 100 microM menadione for 24 hours. Using electron microscopy technique cell...

Background: Knowledge about Immune-Mediated Necrotizing Myopathy (IMNM) has received significantly attention in recent years. In this study, we report a rare case of IMNM with increased Creatine Phosphokinase (CPK) and positive Signal Recognition Particle (SRP). Clinical Presentation and Intervention: The case was a 67-year-old male patient referred to Firozgar hospital affiliated to the Iran ...