CONTEXT It is well recognized that celiac disease is an immune-mediated systemic disorder highly prevalent among relatives of celiac patients. OBJECTIVES The aim of this study is to determine the prevalence of celiac disease in a group of first degree relatives of celiac children, and to access the frequency of human leukocyte antigen HLA-DQ2 and DQ8 in celiac disease patients and their affec...

BACKGROUND Initial publications examining the hereditary aspects of endometriosis appeared in the early seventies and demonstrated an up to seven-fold risk for endometriosis in first-degree relatives of endometriosis patients. The aim was to evaluate the influence of hereditary aspects on the endometriosis risk in our patient collective. METHODS In a retrospective cohort study we evaluated th...

The risk of suicide among the first-degree relatives of 195 schizophrenic and 315 manic-depressive patients in a long-term study was estimated. The findings demonstrate a higher risk of suicide among relatives of psychiatric patients in comparison with relatives of surgical controls. Male relatives had a higher risk of suicide than female relatives. When suicide risk in the relatives was analyz...

Evidence exists for the presence of a specific facial phenotype in nonaffected first-degree relatives of persons with CL/P. An increased risk for olfactory dysfunction has also been reported in CL/P-relatives. These phenotypic features can probably be explained via the presence of CL/P-related susceptibility genes. We aimed at confirming the occurrence of these endophenotypic traits in first-de...