CONTEXT The GnRH receptor plays a central role in regulating gonadotropin synthesis and release, and several mutations in the GNRHR gene have been reported in patients with idiopathic or familial forms of isolated hypogonadotropic hypogonadism (IHH). OBJECTIVE The objective of the study was to investigate whether partial loss-of-function mutations in the GnRH receptor might be responsible for...

The purpose of this study was to investigate the hydrolyzation of aspirin during the process of dissolution testing for aspirin delayed-release tablets. Hydrolysis product of salicylic acid can result in adverse effects and affect the determination of dissolution rate assaying. In this study, the technique of differential spectra was employed, which made it possible to monitor the dissolution t...

Meadow, S. R., and Leeson, G. A. (1974). Archives of Disease in Childhood, 49, 310. Poisoning with delayed-release tablets: treatment of Debendox poisoning with purgation and dialysis. Accidental poisoning with delayedrelease tablets causes symptoms at a time when the tablets can no longer be retrieved from the stomach. A child died from eating 23 tablets of Debendox, which is a delayed-release...

constitutively phosphorylated RyR2 at Ser2814 showed a higher incidence of Ca sparks and increased susceptibility to pacing-induced AF compared with controls. The relationship between [Ca ]i and INCX density revealed INCX upregulation in cAF. Spontaneous Ca release events accompanied by inward INCX currents and delayed afterdepolarizations/triggered activity occurred more often and the sensitiv...

We consider a tandem queue with two stations. The first station is an s-server queue with Poisson arrivals and exponential service times. After terminating his service in the first station, a customer enters the second station to require service at a single server, while in the meantime he is blocking his server in station 1 until he completes service in station 2, whereupon the server in stati...

Dexlansoprazole MR is a modified release formulation of the R-enantiomer of lansoprazole, which employs a novel Dual Delayed Release (DDR) technology. Pharmacokinetic studies have shown that the DDR technology provides a two peaks drug release, accuring 1–2 hours and 4–5 hours after dosing, leading to an extended duration of therapeutic plasma drug concentrations compared with conventional dela...

BACKGROUND Limitations associated with the under-reporting of enteric illnesses have long been recognized but the extent and variation of this under-reporting in Canada has not been examined. Given the public health value of surveillance data, a closer examination of under-reporting of enteric illnesses in Canada was warranted. METHODS Paper-based surveys were administered (a) to all laborato...

Star fruit juice is a potent in vitro inhibitor of CYP3A; however, few reports are available on the inhibition of CYP3A activities by star fruit juice in vivo. Therefore, in this study, we investigated the CYP3A-mediated star fruit-drug interaction in vivo. The effect of star fruit juice on carbamazepine pharmacokinetics was examined in rats. In comparison with water, the area under the concent...

About 3 to 12% of the energy consumed by ruminants (cattle and sheep) is converted to methane in the rumen (referred to as enteric methane) and released into the atmosphere. Adopting feeding strategies that will minimize the amount of energy, lost as methane, can improve feed conversion efficiency, improve animal productivity, and is good for the environment. Producers can reduce their herd's m...