Expression of the yeast mitochondrial cytochrome b gene (COB) is controlled by at least 15 nuclear-encoded proteins. One of these proteins, Cbp1, is required for COB mRNA stability. Delta cbp1 null strains fail to accumulate mature COB mRNA and cannot respire. Since Delta cbp1 null strains lack mature COB transcripts, the hypothesis that Cbp1 also plays a role in translation of these mRNAs coul...

BACKGROUND Epoetin delta is an epoetin that, unlike existing agents, is produced in a human cell line. The present study investigated the efficacy and tolerability of intravenous (i.v.) epoetin delta compared with i.v. epoetin alfa. METHODS This was a 6-month, multicentre, randomized, double-blind trial in haemodialysis patients previously receiving epoetin alfa. Haematological parameters wer...

The effect of the protein matrix on the standard potential of a buried redox center has been investigated by using a selection of mutants and chemical derivatives in Saccharomyces cerevisiae cytochrome c isoform 1. Assuming only local structural perturbation and no alteration of the iron-ligation chemistry, Delta E(m)(0)' can be regarded as a measure of the difference in polypeptide solvation o...

Large, multisubunit Ccr4-Not complexes are evolutionarily conserved global regulators of gene expression. Deletion of CCR4 or several components of Ccr4-Not complexes results in abnormally large cells. Since yeast must attain a critical cell size at Start to commit to division, the large size of ccr4 delta cells implies that they may have a size-specific proliferation defect. Overexpression of ...

In vivo metabolism of tibolone was studied in three healthy postmenopausal volunteers after daily oral administration of 2.5 mg of tibolone for 5 days and a single dose of 2.5 mg approximately equal 555 kBq of [(14)C]tibolone on day 6. The 0- to 192-h recovery of radioactivity in urine and feces was 31.2 +/- 10.5 and 53.7 +/- 5.1%, respectively. Total 0- to 192-h recovery ranged from 78.5 to 94...

Abstract. In this paper we shall develop a theory of (extended) double shuffle relations of Euler sums which generalizes that of multiple zeta values (see Ihara, Kaneko and Zagier, Derivation and double shuffle relations for multiple zeta values. Compos. Math. 142 (2)(2006), 307–338). After setting up the general framework we provide some numerical evidence for our two main conjectures. At the ...

let a be a unital algebra over a field of characteristic zero. we show that every derivation from( ) n m a into its dual ( ) n m a ∗ is the sum of an inner derivation and a derivation induced by a derivationfrom a into a∗

We have examined the fatty acid substrate specificity of arachidonoyl-CoA synthetase from human platelet membranes. A variety of positional isomers and chain-length analogs of arachidonic acid [20:4(5, 8, 11, 14)] were synthesized, and assayed for their ability to inhibit arachidonoyl-CoA formation or to serve as substrates for the synthetase. The chain-length specificity of the synthetase for ...

Bu çalışmada u^2=1 olmak üzere 〖S=Z〗_8+uZ_8 halkası üzerindeki aykırı devirli ve çift (double) kodlar çalışılmıştır. θ, S üzerinde bir otomorfizm δ_θ türetim (derivation) S[x,θ,δ_θ ] polinomlar tanımlanmıştır. δ_θ-devirli tanımlanarak bu kod ailesinin bazı cebirsel özellikleri incelenmiştir. Ayrıca sınıfının genellemesi olan