Opioid receptor subtypes may have site-specific effects and play different roles in modulating serotonergic neurotransmission in the mammalian central nervous system. To test this hypothesis, we used in vivo microdialysis to measure changes in extracellular serotonin (5-hydroxytryptamine; 5-HT) in response to local infusion of mu-, delta-, and kappa-opioid receptor ligands into the dorsal raphe...

For a ring endomorphism $alpha$ and an $alpha$-derivation $delta$, we introduce a concept, so called skew $pi$-Armendariz ring, that is a generalization of both $pi$-Armendariz rings, and $(alpha,delta)$-compatible skew Armendariz rings. We first observe the basic properties of skew $pi$-Armendariz rings, and extend the class of skew $pi$-Armendariz rings through various ring extensions. We nex...

BACKGROUND There are few data on the quantitative effects of cigarette smoking on lung function in young adults. These effects are important in the understanding of the early stages of chronic airflow obstruction. METHODS A longitudinal study over eight years was carried out to estimate quantitatively the effect of cigarette smoking on ventilatory lung function in young adults and to examine ...

This article examines annihilators in the skew polynomial ring $R[x;alpha,delta]$. A ring is strongly right $AB$ if everynon-zero right annihilator is bounded. In this paper, we introduce and investigate a particular class of McCoy rings which satisfy Property ($A$) and the conditions asked by P.P. Nielsen. We assume that $R$ is an ($alpha$,$delta$)-compatible ring, and prove that, if $R$ is ni...

background: coronary artery disease (cad) is the major cause of mortality and morbidity worldwide. the aim of this study was to explore the effect of resveratrol (res) on canonical β-catenin/wnt and forkhead box o (foxo) pathways in cad patients.method: we performed this study on 10 metabolic syndrome patients with three-vessel cad and 10 sex-aged matched healthy subjects. the effects of res on...

In this study, a mixed $delta$-shock model with discrete-time is defined by combining $delta$-shock and extreme shock models. In this model, a system with multiple states fails in two ways: first, when k interarrival times between two consecutive shocks with magnitude larger than the critical threshold $gamma$ are in $[delta_1, delta _2], delta_1 < delta _2$; and second, when the interarrival t...

Adiponectin influences insulin sensitivity and lipid metabolism, but it is not clear whether these effects are correlated with fat mass or distribution. We studied the relationship between plasma adiponectin and leptin levels, insulin sensitivity, and serum lipids by a cross-sectional study (n = 242 subjects) and by an intervention study (95 of 242) to evaluate the effect of weight loss (WL). C...

Peroxisome proliferator-activated receptor beta/delta (PPARbeta/delta) has emerged as a powerful metabolic regulator in diverse tissues including fat, skeletal muscle, and the heart. It is now established that activation of PPARbeta/delta promotes fatty acid oxidation in several tissues, such as skeletal muscle and adipose tissue. In muscle, PPARbeta/delta appears to act as a central regulator ...

Repeated exposure to human immunodeficiency virus (HIV) does not always result in seroconversion. Modifications in coreceptors for HIV entrance to target cells are one of the factors that block the infection. We studied the frequency of Delta-32 mutation in ccr5 gene in Medellin, Colombia. Two hundred and eighteen individuals distributed in three different groups were analyzed for Delta-32 muta...