Formation of delusions in the phase of acute psychosis is based on two subsequent processes. The first one is dopamine hyperactivity in mesolimbic neural pathways, the second one is a cognitive process of up-down attribution of meanings of this subjectively perceived state of mind by the higher levels of brain. After the successful antipsychotic treatment, the subjectivity of patients changes. ...

This study examined whether levels of emotional distress and impairments in visual memory were uniquely associated with severity of delusions in schizophrenia. Severity of delusions was assessed using select items from the positive component of the Positive and Negative Syndrome Scale among 44 persons with schizophrenia or schizoaffective disorder in a post-acute phase of illness. Emotional dis...

OBJECTIVE Psychotic-like experiences (PLE) in the general community are common. The aims of this study were to examine the prevalence and demographic correlates of PLE in young adults. METHOD The sample consisted of 2441 subjects aged 18-23 years. Subjects completed the Composite International Diagnostic Interview (CIDI) and the 21-item Peters Delusional Inventory (PDI). Associations between ...

Background Delusions, a core symptom of schizophrenia, are thought to arise from an alteration in predictive coding mechanisms that underlie perceptual inference. Here, we aimed to empirically test the hypothesized link between delusions and perceptual inference. Method 28 patients with schizophrenia and 32 healthy controls matched for age and gender took part in a behavioral experiment that ...

The ability to challenge and revise thoughts prompted by anomalous experiences depends on activity in right dorsolateral prefrontal circuitry. When activity in those circuits is absent or compromised subjects are less likely to make this kind of correction. This appears to be the cause of some delusions of misidentification consequent on experiences of hyperfamiliarity for faces. Comparing the ...