Dendrite arbor structure is a critical determinant of nervous system function that must be actively maintained throughout life, but the signaling pathways that regulate dendrite maintenance are essentially unknown. We report that the Abelson (Abl) and Abl-related gene (Arg) nonreceptor tyrosine kinases are required for maintenance of cortical dendrites in the mouse brain. arg-/- cortical dendri...

The RhoA (Rho) GTPase is a master regulator of dendrite morphogenesis. Rho activation in developing neurons slows dendrite branch dynamics, yielding smaller, less branched dendrite arbors. Constitutive activation of Rho in mature neurons causes dendritic spine loss and dendritic regression, indicating that Rho can affect dendritic structure and function even after dendrites have developed. Howe...

In this paper, the ((CoCrFeNi)95Nb5)100?xMox (x = 1, 1.5 and 2) high-entropy alloy (HEA) coatings were fabricated on substrate of 45# steel by laser cladding process under different beam power. The influence power molybdenum element content microstructure microhardness HEA was investigated. Results show that composed face-centered cubic (FCC) phase Laves phase, had low porosity, bonded well to ...

The formation of a complex nervous system requires precise navigation and elaboration for growth cone and dendrites to connect to their target. During development, guidance molecules and receptors control the majority of the circuitry events, including promotion or inhibition of neurite growth. Semaphorin 3A, a secreted Class 3 Semaphorin member, is well known for its chemorepellent function on...

Cortical inhibitory neurons play crucial roles in regulating excitatory synaptic networks and cognitive function and aberrant development of these cells have been linked to neurodevelopmental disorders. The secreted neurotrophic factor Neuregulin-1 (NRG1) and its receptor ErbB4 are established regulators of inhibitory neuron connectivity, but the developmental signalling mechanisms regulating t...

A neuron has two types of highly polarized cell processes, the single axon and multiple dendrites. One of the fundamental questions of neurobiology is how neurons acquire such specific and polarized morphologies. During neuronal development, various actin-binding proteins regulate dynamics of actin cytoskeleton in the growth cones of developing axons. The regulation of actin cytoskeleton in the...