Although the role of acetate as a substrate for steroid biosynthesis in systems in vitro is now well established (l-4), the role of mevalonate is currently somewhat obscure. A number of conflicting reports on the utilization of the latter substance for steroidogenesis have appeared in the literature. The diversity of steroidogenic tissue preparations that have been tested for their ability to u...

In vitro responsiveness of endometrial adenocarcinoma to progestins was evaluated histologically by incubation of tissue fragments in medium containing 10(-6) M medroxyprogesterone acetate. In a series of 19 experiments, formation of sub- and supranuclear vacuoles, which reflects accumulation of glycogen in response to medroxyprogesterone acetate added to the medium, was observed in well-preser...

In vitro responsiveness of endometrial adenocarcinoma to progestins was evaluated histologically by incubation of tissue fragments in medium containing 10~6 M medroxyprogesterone acetate. In a series of 19 experiments, formation of suband supranuclear vacuoles, which reflects accumulation of glycogen in re sponse to medroxyprogesterone acetate added to the medium, was observed in well-preserved...

Various synthetic progestogens that are used as contraceptives have been reported to influence lipid and lipoprotein fractions differently. Depo-medroxyprogesterone acetate (DMPA), a synthetic progestogen, is used by Nepalese women as a contraceptive agent. Our study aims to determine the effects of long-term use of DMPA on lipid metabolism. We performed this study on 60 healthy Nepalese women ...

Chicken seminal plasma contains a high content of sex steroids including progesterone (P4). According to a published study, in vitro supplementation of P4 to the semen resulted in decreased fertility in the White Leghorn chicken; however, it is not known if increased P4 production in vivo is associated with decreased sperm fertility. Therefore, the aim of the present experiment was to study the...

gonad. Please refer to our general review". In the past studies on the biosyn thesis, emphasis was laid on the elucidation of production route of sex hormones . The route established to date runs thus : Acetate• ̈cholesterol-, 22-hydroxy cholesterol pregnenolone • ̈ progesterone • ̈17-hydroxy progesterone-• ̈ƒ¢4-and rostene-3, 17-dione• ̈19-hydroxy-ƒ¢4-and rostenedione-,estrone->estradiol-17ƒÀ , but...

PURPOSE We compared the immediate administration of DMPA (Depo Now) to the immediate use of short-term hormonal methods that served as a "bridge method" until later DMPA initiation. We examined whether Depo Now, as compared to initiating with a bridge method (pills, transdermal patch, or vaginal ring), resulted in greater DMPA continuation at six months. METHODS Young women aged 14 to 26 year...

Medroxyprogesterone acetate (MPA: Depo-Provera) is a long-acting synthetic progestin that has been used as a contraceptive for more than 11 million women-years in 80 nations [1]. The U.S. Food and Drug Administration has denied approval of MPA as a contraceptive because of concern about its safety, especially teratogenicity and carcinogenicity [2.3]. In addition to its contraceptive action, MPA...