The aim of this paper was to confirm the efficacy of adrenocorticotropin depot (ACTH-depot) therapy in pregnancies with threatened miscarriage and preterm delivery through the desired stimulation of the adrenal glands controlled by the rest of organism. The activity of hypothalamic-pituitary-adrenal axis plays a key role in pregnancy. Such naturally stimulated endogenous corticosteroid hormones...

The fatty acid Composition of lipids from erythrocytes and depot fat of rats whose diet wac supplemented with various levels of linoleate, arachidonate, or linolenate has been investigated. Dietary linoleate and linolenate are incorporated into the depot fat. The ratio of eicosatrienoic acid to eicosatetraenoic acid, derived from the analysis of depot fat, decreases with increasing amounts of a...

This paper studies the double traveling salesman problem with two stacks. A number of requests have to be served where each request consists in the pickup and delivery of an item. All the pickup operations have to be performed before any delivery can take place. A single vehicle is available that starts from a depot, performs all the pickup operations and returns to the depot. Then, it performs...

Upper-body adiposity is associated with increased metabolic disease risk, while lower-body adiposity is paradoxically protective. Efforts to understand the underlying mechanisms require appropriate and reproducible in vitro culture models. We have therefore generated immortalised (im) human preadipocyte (PAD) cell lines derived from paired subcutaneous abdominal and gluteal adipose tissue. Thes...

The depot model, developed at Carnegie Mellon University, provides a method for managing third-party and locally developed software. depot uses an object-oriented approach to managing software; each software package is managed as one or more logical objects. Yet, from the perspective of a user, the multiple ‘‘software objects’’ appear as a single, integrated, software environment. Local disk de...

As pointed out by Nagy and Salhi in their recent survey [1], many variants of the location routing problem (LRP) are addressed in the literature. Generally speaking the LRP consists of determining locations for depots from which customers are served on routes with the objective of minimizing the overall cost. In this talk we consider the capacitated locationrouting problem (CLRP) which is defin...

PURPOSE To assess change in hospitalization and cost of care from 6 months pre- to 6 months post-initiation on any depot antipsychotic among schizophrenia patients. PATIENTS AND METHODS Using a large United States commercial claims and encounters database, patients younger than 65 years diagnosed with schizophrenia were identified. Patients initiated on a depot antipsychotic were studied in a...

Logistics and supply-chain management may generate notable operational cost savings with increased reliance on shared serving of customer demands by multiple agents. However, traditional logistics planning exhibits an intrinsic limitation in modeling and implementing shared commodity delivery from multiple depots using multiple agents. In this paper, we investigate a centralized model and a heu...

The generalized multiple depot traveling salesmen problem (GMDTSP) is a variant of the multiple depot traveling salesmen problem (MDTSP), where each salesman starts at a distinct depot, the targets are partitioned into clusters and at least one target in each cluster is visited by some salesman. The GMDTSP is an NP-hard problem as it generalizes the MDTSP and has practical applications in desig...

0957-4174/$ see front matter 2011 Elsevier Ltd. A doi:10.1016/j.eswa.2011.03.077 ⇑ Corresponding author. Tel.: +90 212 3832868. E-mail addresses: [email protected] (G.N. Y (N.Ç. Demirel). In this paper, a new type of geometric shape based genetic clustering algorithm is proposed. A genetic algorithm based on this clustering technique is developed for the solution process of the multi-depot...