Twoand three-dimensional sub-surface optical beam induced current imaging of a silicon flip-chip is described and is illustrated by results corresponding to 166 nm lateral resolution and an axial performance capable of localising feature depths to around 100 nm accuracy. The experimental results are compared with theoretically modelled performance based on analytic expressions for the system po...

13C labeling is introduced as a tracer for depth profiling of polymer films and multilayers using secondary ion mass spectrometry (SIMS). Deuterium substitution has traditionally been used in depth profiling of polymers but can affect the phase behavior of the polymer constituents with reported changes in both bulk-phase behavior and surface and interfacial interactions. SIMS can provide contra...

Bombardment with C60+ primary ions of monolayer and multilayer barium arachidate Langmuir-Blodgett (LB) films is investigated. The behavior of cluster versus atomic (Ga+) bombardment is monitored by the barium-cationized arachidate ion (mass-to-charge ratio (m/z) 449) and a characteristic fragment ion (m/z 209) using 1-, 7-, and 15-layer model systems. The removal rate of material from the film...

Content profiling in digital preservation is a crucial step that enables controlled management of content over time. However, large-scale profiling is facing a set of challenges. As data grows and gets more diverse, the only option to control it is to combine outputs of multiple characterization tools to cover the varieties of formats and extract features of interest. This cooperation of tools ...

We utilized monochromatic high energy synchrotron x-rays (100 keV) to perform transmission diffraction measurements on bulk cadmium zinc telluride (Cd1-xZnxTe, x ~ 0.1) crystals used for room temperature radiation detectors. The highenergy measurements assess the crystalline properties throughout the thickness (2-3 mm) of the structures and we determined in combination with standard high-resolu...

Uveal melanoma (UM), the most common primary intraocular tumour in adults, is characterised by a high frequency of metastases to the liver, typically with a fatal outcome. Proteins secreted from cancer cells ('secretome') are biologically important molecules thought to contribute to tumour progression. We examined the UM secretome by applying a label-free nanoLCMS/MS proteomic approach to profi...

Ultra shallow dopant profiles are one of the major challenges for ULSI silicon metrology. Following the ITRS 2002, the 90nm technology node will appear in 2004 along with the maximum drain extension in the range of 15-25 nm for both P-MOS and N-MOS devices. In this frame, a very abrupt junction with a decay length of 4 nm/decade is mandatory. A depth resolution better than 0.7 nm in profiling s...

The Lia system, a cell envelope stress response module of Bacillus subtilis, is comprised of the LiaRS two-component system and a membrane-anchored inhibitor protein, LiaF. It is highly conserved in the Firmicutes bacteria, and all orthologs investigated so far are activated by cell wall antibiotics. In response to envelope stress, the systems in Firmicutes cocci induce the expression of a numb...