Hair follicle development and growth are regulated by Wnt signalling and depend on interactions between epidermal cells and a population of fibroblasts at the base of the follicle, known as the dermal papilla (DP). DP cells have a distinct gene expression signature from non-DP dermal fibroblasts. However, their origins are largely unknown. By generating chimeric mice and performing skin reconst...

Abstract Hidradenitis suppurativa (HS) is a chronic recurrent debilitating condition. It characterized by abscesses, and can be complicated rupture, scarring sinuses. The management of HS multidisciplinary, involving general lifestyle modification, medical treatment, surgery. A wide range surgical interventions have been described for disease control management. However, strategies are highly v...

Tissue-engineered constructs need to become quickly vascularized in order to ensure graft take. One way of achieving this is to incorporate endothelial cells (EC) into the construct. The adipose tissue stromal vascular fraction (adipose-SVF) might provide an alternative source for endothelial cells as adipose tissue can easily be obtained by liposuction. Since adipose-EC are now gaining more in...

A 50-year-old man was transferred to a level I trauma center for penetrating injury. Industrial metal had penetrated his trunk, and he injured in internal organs. The organs were treated by the surgery team. peritoneum reconstructed with artificial dermal matrix graft. wound managed negative-pressure therapy, several debridement procedures performed. full-thickness abdominal defect covered mono...

Background and Objectives Interposition using acellular allograft between perforated septal flaps is a popular procedure among surgeons because of its usefulness. However, dermal matrix itself tends to become infected sometimes, can easily undergo necrosis or be displaced from the implanted site. Here, authors would like introduce newly devised interposition graft made up cartilage, which easy ...

(1) Background: Pelvic organ prolapse (POP) is common among post-menopausal women affecting more than 25% in their lifetime—with 11% having a lifetime risk of undergoing an operation for POP. In April 2019, the Food and Drug Administration (FDA) took surgical mesh transvaginal use off market due to safety effectiveness concerns. This leaves colporrhaphy or with bio-graft options POP repair. (2)...

This study aims to explore the influence of hyaluronic acid (HA) on wound healing during xenogeneic porcine acellular dermal matrix (PADM) composite skin grafting. The results will facilitate the development of methods for improving graft contracture and poor elasticity of composite transplantation. Exogenous HA was added to composite PADM grafts and to thin autologous skin grafts during rabbit...

BACKGROUND Coverage of roots exposed by gingival recession is one of the main objectives of periodontal reconstructive surgery. A large variety of mucogingival grafting procedures are available. However, the long-term effectiveness of this procedure is still not clear. This study compared the effectiveness of sub-pedicle acellular dermal matrix allografts with subepithelial connective tissue au...