Comment The patient is presented for the following reasons: (1) To emphasize that generalized itching seems to be a common precursor of scleroderma and dermatomyositis. Three of our last 7 patients with scleroderma and 2 of the last 3 with dermatomyositis have had puritus for one to five years before these diagnoses were made. (2) To invite comment about the diagnosis as to whether this is gene...

a change in proinflammatory plasma cytokine profile of patients with juvenile dermatomyositis correlating with disease activity Juvenile dermatomyositis ( JDM) is a rare autoimmune disorder, affecting mainly muscles and skin. The mainstay of treatment is high dose corticosteroids, combined with other immunosuppressive drugs. In about 30% of patients, the disease cannot be controlled despite mul...

Dermatomyositis and its association with malignancy is well known. Though many tumors like breast, ovary, lung carcinomas are reported to be associated with it, cervical carcinoma is a very rare one. Tumors in these patients are usually unmasked by abnormal findings in the medical history and physical examination. Here we report case of a postmenopausal female who presented with subacute onset ...

Background: Dermatomyositis is a multi organ autoimmune disease wich commonly complicated with interstitial lung disease. Chest high-resolution computed tomography (HRCT) still considered the diagnostic gold standard for and quantification, however he increasing use of ultrasound may play an important role in future. Objectives: The aim our study was to determine value detection progression pul...

Hydroxyurea (HU) is a chemotherapeutic agent used for the treatment of myeloproliferative disorders such as chronic myeloid leukemia, polycythemia vera, and essential thrombocytosis. We describe a 69-year-old man who had essential thrombocytosis and developed amyopathic dermatomyositis after long-term HU therapy. He presented with Gottron papules and heliotrope erythema. The former has been des...

A 67-year-old man developed dermatomyositis. Investigation revealed an oat cell carcinoma of the lung. When he developed unilateral gynaecomastia this tumour was found to secrete gonadotrophins. The gynaecomastia disappeared after treatment with an anti-oestrogen--tamoxifen. This use of tamoxifen has not previously been described. Partial tumour regression was obtained with several cytotoxic dr...