The FDA's new "breakthrough therapy" designation for investigational drugs adds to the agency's portfolio of expedited programs for serious conditions. The designation requires preliminary clinical evidence demonstrating substantial improvement over existing therapies.

1. Sustainable development Today, the concept of sustainability significantly affects our life and economic activities. In 1987, the Bruntland Commission stated: “Humanity has the possibility of making development sustainable, i.e. ensuring that the needs of the present are met without compromising the ability of future generations to meet their own needs” (World Commission for environment and ...

one of the most highly applicable evidences for inference of legal precepts is the isolated tradition, whose acceptance, rejection, or limitation is highly effective in the consequences of inference. muḥaqqiq ardabīlī, as one of the geniuses of imāmī jurisprudence in tenth/ sixteenth century, with his special attitude toward this source of inference of precepts, has regarded only the validity o...

A study was conducted to evaluate the quality and sensory properties of protected designation of origin (PDO) Parma ham and Piacentina neck obtained from heavy pigs (Italian Duroc × Italian Large White) fed barley-based diets. Four diets were tested: 1) a corn-based diet (control), 2) the control diet with 80% of a normal-amylose hulled barley variety (Cometa), 3) the control diet with 80% of a...

Lamb meat quality of two Portuguese products was examined. The influences of slaughter weight, sex and breed on eating quality were evaluated. Data were obtained from 72 lambs of two different breeds with protected designation origin. In accord with the normal slaughter weight in the region three classes were considered: A: 9-14kg live weight; B: 14-19kg live weight and C: 19-24kg live weight. ...

We present radial velocity measurements of four wide halo binary candidates from the sample in Chaname & Gould (2004; CG04) which, to date, is the only sample containing a large number of such candidates. The four candidates that we have observed have projected separations > 0.1 pc, and include the two widest binaries from the sample, with separations of 0.45 and 1.1 pc. We confirm that three o...

one of the recent inquiries in the field of hadith studies is the investigation of transferred traditions and their causes and impacts on shi‘i hadith circles. by exploring some traditions in the hadith collection of al-shaykh al-saduq and comparing the textual similarities and also the chain of transmitters, this research attempts to show that traditions of jewish origin in the shi‘i hadith ci...