Recently, we created a family of engineered G protein-coupled receptors (GPCRs) called DREADD (designer receptors exclusively activated by designer drugs) which can precisely control three major GPCR signaling pathways (Gq, Gi, and Gs). DREADD technology has been successfully applied in a variety of in vivo studies to control GPCR signaling, and here we describe recent advances of DREADD techno...

BACKGROUND Historically substance misuse has been relatively common in western countries, but comparatively few Finns report drug use. The Drugs 2020 study aimed at foreseeing changes in the drug situation in Finland by the year 2020. METHODS The Delphi method was used, utilizing drug experts of the EU national network in Finland. RESULTS Marked growth was foreseen in drug use, especially i...

The characterization of pro-poor growth, including the sources through which the poor benefit from public interventions, remains a topic of debate in the current development literature. This paper examines the impact of a range of policies across villages in rural Bangladesh (spanning credit and infrastructure expansion, as well as agricultural output pricing) not only on different sources of i...