PREVIOUS observations 1 have shown that rats, pretreated with 2-methyl-9a-chlorocortisol (Me-Cl-COL) and an excess of dietary phosphate, develop massive myocardial necroses within a few hours following exposure to various stressor agents. Me-Cl-COL is an artificial synthetic steroid which does not occur in nature; it possesses rather unusual pharmacologic properties in that it is not only extra...

The administration of adrenal steroids to animals and human subjects on diets containing sodium but little or no potassium is followed by alterations in cellular composition characterized by a loss of potassium which is partially replaced by sodium and the supervention in the extracellular fluid of a metabolic alkalosis.' The experiments have been performed principally in rats where the sodium ...

Rats received electrolytic lesions centered in the gustatory subnucleus of the ventral posterior complex of the thalamus. They were tested for impairments of the ability to increase sodium chloride intake after depletion of body sodium or treatment with the mineralocortieoid desoxycorticosterone. Tests were administered either within a few weeks or after 2 months postoperative recovery to test ...

tion between ARC/IRCand the presence of nephropathy, neuropathy and retinopathy in the 4 groups were examined. Responses of aldosterone and its precursors, 1 1 -desoxycorticosterone (DOC), corticosterone (B) and 18-hydroxy-corticosterone (1 8-OHB) to ACTHor angiotensin II (A II) were measured in normal subjects and in the 4 groups of diabetic patients in order to examineadrenal biosynthesis in ...

In recent years it has become increasingly evident that a depletion of body potassium may occur in a number of conditions. The relationship of a fall in the serum potassium to the attacks of -familial periodic paralysis is well known. Potassium deficiency has also been found in infantile diarrhoea, intestinal obstruction with vomiting, sprue, renal insufficiency, diabetic coma, Addison's diseas...

Renin and erythropoietin activities were measured in the plasma of 110 rats exposed to various conditions designed to dissociate the two renal "hormones." In acute experiments, intraperitoneal injection of polythiazide increased renin activity but did not change erythropoietin activity; exposure to low oxygen tension increased erythropoietin activity and caused an insignificant decrease in reni...

Adrenalectomized sheep with a single kidney were maintained chronically hypertensive after renal arterial constriction on a maintenance dosage of desoxycorticosterone acetate and cortisone acetate. This level of steroid support is totally without pressor effects in adrenalectomized animals with normal kidneys. Blood pressure was monitored after steroid withdrawal with (1) no replacement of Na l...

I was born in San Diego, California, in 1961. My brother Mark was born in January of the previous year. My father Kenneth Greider was a physicist who had recently graduated with a PhD from University of California at Berkeley. My mother Jean Foley Greider also had received her PhD from UC Berkeley in botany. My father worked high-energy nuclear physics and my mother was a mycologist and a genet...

I thought long and hard whether I could avoid talking about family and personal life, and just share the excitement of being a scientist and how science continues to sustain us all. But so many people, especially younger scientists, want to know-and always ask-How did you do it? A woman from Iran, a Middle Eastern country and essentially Muslim, now considered backwards and misguided if not dow...