The article presents the results of a review publications devoted to study problems drug-induced liver damage in inflammatory bowel diseases (IBD). hepatotoxic effect thiopurines (azathioprine and 6-mercaptopurine) — hepatotoxicity from 0% 17%; sulfasalazine mesalamine (hepatotoxicity 4%); methotrexate 15% 50%); tumor necrosis factor inhibitors up 75% cases.), anti-integrins 2% 5%); an interleu...

The aim of this study was to determine the association of n-acetyltransferase-2 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity in Iranian pulmonary tuberculosis patients. Acetylating phenotypes was studied in 50 Iranian pulmonary tuberculosis patients using metabolic ratio of plasma acetyl-Isoniazid to Isoniazid. The association between hepatotoxicity and the n-acetyltransferas...

The complex and multifactorial nature of neuropsychiatric diseases demands multi-target drugs that can intervene with various sub-pathologies underlying disease progression. Targeting the impairments in cholinergic glutamatergic neurotransmissions small molecules has been suggested as one potential disease-modifying approaches for Alzheimer’s (AD). Tacrine, a potent inhibitor acetylcholinestera...

Abstract Hydrazine is a hazardous chemical commonly used as a reactant in rocket and jet fuel cells. Animal studies have demonstrated hepatic changes after hydrazine inhalation. Human case reports of hydrazine inhalation hepatotoxicity are rare. We report a case of mild hepatotoxicity following brief hydrazine vapour inhalation in a healthy young man, which resolved completely on expectant mana...