This experiment aimed to investigate the effects of the chitosan (CTS) and water-soluble chitosan (WSC) microspheres on plasma lipids in male Sprague-Dawley rats fed with high-fat diets. CTS microspheres and WSC microspheres were prepared by the spray-drying technique. Scanning electron microscopy (SEM) micrographs showed that the microspheres were nearly spherical in shape. The mean size of C...

Microspheres of biodegradable polymers were evaluated as a potential controlled-release drug-delivery system in the vitreous. The microspheres were prepared with polymers of poly(lactic acid) or copolymers of glycolic acid and lactic acid. The release of 5-fluorouracil (5-FU) from the microspheres was studied in vitro. Poly(lactic acid) microspheres released 70-85% of total 5-FU over 7 days. Mi...

Microspheres are multiparticulate drug delivery systems that distribute medications at a predetermined rate to specific region. free-flowing powders manufactured from biodegradable proteins or synthetic polymers, with particle sizes ranging 1 1000 micrometers. Benefits of using microspheres in medication delivery, bone tissue manufacture, and pollutant absorption desorption by regeneration .The...

The first life was believed to emerge in the early Earth via a process involving synthesis of organic compounds and formation protocells. However, it is still puzzle how protocell with hierarchal structure desirable functions spontaneously generated non-living environment composed mainly water minerals. In this work, using muscovite as an example minerals, we systemically studied coacervation p...

PURPOSE To evaluate the in vivo and in vitro properties of collagen-coated acrylic microspheres and to compare them with polyvinyl alcohol (PVA) particles. METHODS Samples of 100- to 300-microns, 300- to 500-microns, 500- to 700-microns, and 700- to 900-microns collagen-coated acrylic microspheres and 200- to 300-microns PVA particles were suspended in solutions of 50% saline and 50% contrast...

The objective of this work was to develop and evaluate reconstitutable suspensions of ibuprofen-loaded microspheres prepared with an acrylic polymer (Eudragit RS-PM). The microspheres were prepared by the quasi-emulsion solvent diffusion technique. To prepare reconstitutable suspension formulation, the microspheres used had a mean particle size of 316.6 microm and 99.8% loading efficiency. Xant...

a multiple-unit oral floating system was prepared using the emulsification-solvent diffusion method to prolong the gastric emptying time of theophylline. for this purpose, theophylline, ethyl cellulose and dibutyl phthalate were dissolved in an ethanol/dichloromethane mixture, added to 0.1 m hcl containing nacl (20%) or saturated theophylline and/or different concentrations of polysorbate 80 an...

This paper reports a microfluidic synthesis method for manufacturing magnetochromatic microspheres. The magnetochromatic microspheres are magneto-responsive color-changing microparticles in which embedded magnetic nanoparticles diffract different colors of light depending on their nanoscale interparticle spacing within their one-dimensional (1D) arrangements [1]. Our microfluidic approach in co...

The present study envisages formulation of wax microparticulate drug delivery system. The objective of the present study was to minimise the unwanted side effects of Ketoprofene drug formulated by Congealable disperse encapsulation method using biodegradable waxes such as beeswax, ceresin wax microspheres using a wetting agent. Solid, discrete, reproducible free flowing microspheres were obtain...

The purpose of this study was to develop novel lidocaine microspheres. Microspheres were prepared by the oil-in-water (o/w) emulsion technique using poly(D,L-lactide-co-glycolide acid) (PLGA) for the controlled delivery of lidocaine. The average diameter of lidocaine PLGA microspheres was 2.34±0.3 μm. The poly disperse index was 0.21±0.03, and the zeta potential was +0.34±0.02 mV. The encapsula...