Women are more susceptible to numerous stress-linked psychological disorders (e.g., depression) characterized by dysfunction of corticolimbic brain regions critical for emotion regulation and cognitive function. Although sparsely investigated, a number of studies indicate sex differences in stress effects on neuronal structure, function, and behaviors associated with these regions. We recently ...

The microsomal antiestrogen-binding site (AEBS) is a high-affinity membranous binding site for the antitumor drug tamoxifen that selectively binds diphenylmethane derivatives of tamoxifen such as PBPE and mediates their antiproliferative properties. The AEBS is a hetero-oligomeric complex consisting of 3beta-hydroxysterol-Delta8-Delta7-isomerase and 3beta-hydroxysterol-Delta7-reductase. High-af...

The concept of decompressive surgery for treatment of elevated intracranial pressure has been developed already in the beginning of the 20th century.1 The rationale of this treatment modality consists of opening of the skull and removal of a bone flap to allow the edematous brain to swell outward, thereby preventing intracranial tissue shifts and life-threatening downward herniation. The use of...

OBJECTIVE Alcohol addiction too often remains insufficiently treated. It shows the same profile as severe chronic diseases, but no comparable, effective basic treatment has been established up to now. Especially patients with repeated relapses, despite all therapeutic approaches, and patients who are not able to attain an essential abstinence to alcohol, need a basic medication. It seems necess...

Shallow ground-source heat pumps (GSHPs) are a promising technology for contributing to the decarbonisation of energy sector. In heating-dominated climates, combined use GSHPs both heating and cooling increases their technical potential, defined as maximum that can be exchanged with ground, re-injection excess from space leads seasonal regeneration ground. This paper proposes new approach quant...

The ATSP polytope can be expressed by asymmetric polynomial size linear program. Introduction In his seminal work [1], M. Yannakakis proved that the Traveling Salesman problem (TSP) polytope cannot be expressed by symmetric polynomial size linear program, where symmetry means that the polytope is an invariant under vertex relabeling. The question about the size of asymmetric linear programs was...

BACKGROUND: Early postnatal head growth failure is well recognized in very preterm infants (VPIs). This coincides with the characteristic nutritional deficits that occur in these parenteral nutrition (PN) dependent infants in the first month of life. Head circumference (HC) is correlated with brain volume and later neurodevelopmental outcome. We hypothesized that a Standardized, ConcentratedWit...

PRECONCEPTION CARE FOR WOMEN WITH DIABETES Care by an interdisciplinary diabetes healthcare (DHC) team prior to conception and during pregnancy has been shown to minimize maternal and fetal risks in women with diabetes mellitus (1-5). An early working relationship should be established between the woman and the DHC team (composed of diabetes nurse educators, registered dietitians, obstetricians...

BACKGROUND: Early postnatal head growth failure is well recognized in very preterm infants (VPIs). This coincides with the characteristic nutritional deficits that occur in these parenteral nutrition (PN) dependent infants in the first month of life. Head circumference (HC) is correlated with brain volume and later neurodevelopmental outcome. We hypothesized that a Standardized, ConcentratedWit...

Low levels of high-density lipoproteins (HDLs) may constitute an independent risk factor that may be as important as elevated low-density lipoproteins (LDLs) in coronary artery disease (CAD). Concentrations and distributions of lipids, apolipoprotein (apo) B, and apoA-I in the plasma and lipoprotein subfractions of two groups of swine, one with familial hypercholesterolemia (FHC) and the other ...