Post-traumatic stress disorder (PTSD) has been associated with dysregulation of the neuroendocrine system. In this study we examine the effects of psychotherapy in 21 PTSD patients, with and without coexisting depression, on the levels of six stress-related hormones: cortisol, dehydroepiandrosterone (DHEA), and dehydroepiandrosterone-sulfate (DHEA-S), prolactin, thyrotropin (TSH) and free thyro...

Sulfotransferase (ST)-catalyzed sulfation plays an important role in various neuronal functions such as homeostasis of catecholamine neurotransmitters and hormones. Drosophila is a popular model for the study of memory and behavioral manifestations because it is able to mimic the intricate neuroregulation and recognition in humans. However, there has been no evidence indicating that cytosolic S...

Earlier studies have used the dexamethasone (DEX) suppression test (DST) to investigate the hypothalamicpituitary-adrenal (HPA) function in schizophrenia, although the findings are controversial. Recently there has been an increased interest in the role of dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) in HPA axis function. Several studies have investigated basal DHEA(S) levels and corti...

The aim of this research was to study and compare the mechanism of action of interleukin (IL)-8, IL-1beta dehydroepiandrosterone sulphate (DHEA-S) and prostaglandin (PG)E2 on the cervix. Five equal groups of pregnant rabbits (n = 45) were tested by either placebo or tested drugs in the form of vaginal suppositories once daily for 3 days. The suppositories contained human recombinant IL-8 (100 n...

Increased activity of hypothalamic-pituitary-adrenal (HPA) axis and hypersecretion of corticotropin-releasing hormone (CRH) are known to be important factors in pathogenesis of some stress-related diseases. Some neurosteroids exert anxiolytic and antidepressant effects probably by inhibition of HPA axis activity. The aim of our study was to find out if neurosteroids can directly affect human CR...

Dehydroepiandrosterone (DHEA) and its sulphated derivative DHEAS are the most abundant circulating steroids, and are derived from the zona reticularis of the adrenal cortex. The foetal adrenals synthesise signi®cant quantities of DHEA, but production of this steroid falls postnatally. The onset of adrenarche (between the ages of 6 and 8 years) is characterised by increasing biosynthesis of DHEA...

The research aimed to investigate the effect of dehydroepiandrosterone (DHEA) on lipid peroxidation activity and nitric oxide concentration in aorta male Wistar rats due exposure cigarette smoke. This study was a laboratory experiment using 21 that were divided into 3 groups: KN-14 (negative control is given smoke within 14 days), DHEA-1 (15 mg/kgBW + for DHEA-2 (30 days). carried out 25-45 min...

Obesity has been an epidemic in the US and world for more than two decades. Obesity is associated with serious health conditions, including type 2 diabetes, cardiovascular disease, certain types of cancers, hyperlipidemia, and liver steatosis. Nonalcoholic fatty liver disease (NAFLD), a major cause of abnormal liver function, is often associated with obesity. Dehydroepiandrosterone (DHEA) is a ...

Farrukh, Imad S., Wei Peng, Urszula Orlinska, and John R. Hoidal. Effect of dehydroepiandrosterone on hypoxic pulmonary vasoconstriction: a Ca21-activated K1channel opener. Am. J. Physiol. 274 (Lung Cell. Mol. Physiol. 18): L186–L195, 1998.—In the present study, we investigated the effects of the naturally occurring hormone dehydroepiandrosterone (DHEA) on hypoxic pulmonary vasoconstriction (HP...