D epression in children and adolescents with type 1 diabetes has been associated with negative diabetesrelated health outcomes such as poorer glycemic control (1–5) and recurrent diabetic ketoacidosis (DKA) admissions (6,7). While mechanisms that link depression and suboptimal health outcomes are poorly understood (8), it is apparent that the chronicity of type 1 diabetes and the demands of man...

Diabetes mellitus is a widespread disease in the world, despite advances understanding molecular mechanisms of development multifactorial processes associated with this nosology. The review material devoted to modern ideas about immunogenetic causes diabetes, changes metabolism violation carbohydrate metabolism, types and principles laboratory diagnostics accordance WHO criteria. Information on...

T relationship of diabetes to cardiovascular disease has been known for over half a century and has been the subject of a number of reviews. The topic was discussed by the author and two colleagues in 1975, and the present paper concentrates on information published since that time. Although it is well known that diabetic patients commonly die from cardiovascular disease and that cardiovascular...

BACKGROUND Diabetes ketoacidosis (DKA) is a life-threatening complication of type 1 diabetes mellitus (T1DM). Reducing DKA admissions in children with T1DM requires a coordinated, comprehensive management plan. We aimed to decrease DKA admissions, 30-day readmissions, and length of stay (LOS) for DKA admissions. METHODS A multipronged intervention was designed in 2011 to reach all patients: (...

This study was done to characterize the natural course of C-peptide levels in patients with type 1 diabetes and identify distinguishing characters among patients with lower rates of C-peptide decline. A sample of 95 children with type 1 diabetes was analyzed to retrospectively track serum levels of C-peptide, HbA1c, weight, BMI, and diabetic complications for the 15 yr after diagnosis. The clin...

OBJECTIVE More than half of African Americans (AA) with a new diagnosis of diabetic ketoacidosis have clinical and metabolic features of type 2 diabetes during follow-up. This particular presentation of diabetes has been termed as ketosis-prone type 2 diabetes (KPDM) or atypical diabetes. METHODS We review the epidemiology, diagnosis, pathophysiology, and acute and long-term management of AA ...

OBJECTIVE Mutations in the insulin (INS) gene can cause neonatal diabetes. We hypothesized that mutations in INS could also cause maturity-onset diabetes of the young (MODY) and autoantibody-negative type 1 diabetes. RESEARCH DESIGN AND METHODS We screened INS in 62 probands with MODY, 30 probands with suspected MODY, and 223 subjects from the Norwegian Childhood Diabetes Registry selected on...

Diabetic ketoacidosis (DKA) is a severe complication of diabetes mellitus (DM) in children caused by insulin deficiency. This condition often unidentified or diagnosed late, and treated with inadequate therapy. can lead to several complications, the most fatal being cerebral edema. We present two cases DKA different clinical presentation severity. Early identification proper management help imp...

Diabetic ketoacidosis (DKA) is a life-threatening complication of diabetes. The development of metabolic syndrome is widely recognised with the use of atypical antipsychotic agents, and not infrequently DKA has been described with some of these drugs. We describe a complex patient with HIV who presented with severe DKA and prolonged hyperchloraemic acidosis, which we postulate was associated wi...

A 7-year-old girl presented with new onset type 1 diabetes, with moderate diabetic ketoacidosis. She developed clinical and radiologically confirmed cerebral oedema managed with mannitol. Despite slow normalisation of biochemical parameters and marked clinical improvement, she had a further episode of symptomatic cerebral oedema 50 hours following presentation.