نتایج جستجو برای: diabetic cardiomyopathy dcm
تعداد نتایج: 149719 فیلتر نتایج به سال:
OBJECTIVES We sought to identify a novel gene for dilated cardiomyopathy (DCM). BACKGROUND DCM is a heritable, genetically heterogeneous disorder that remains idiopathic in the majority of patients. Familial cases provide an opportunity to discover unsuspected molecular bases of DCM, enabling pre-clinical risk detection. METHODS Two large families with autosomal-dominant DCM were studied. G...
OBJECTIVES Diabetic cardiomyopathy (DCM) is characterized as a coronary heart disease which expands during diabetes due to alterations in the myocardial function and structure. The currentstudy intends to elucidate the protective effect of gingerol on DCM in a streptozotocin (STZ)-induced diabetes mellitus (DM) rat model. MATERIALS AND METHODS In this experimental study, the animals were divi...
Background: Dilated Cardiomyopathy (DCM) is the second most important cause of heart failure in Tanzania, and associated with high mortality. Arrhythmias and/or conduction abnormalities contribute to sudden cardiac death, which occurs up 50% DCM patients. Data on burden factors rhythm patients may help prepare local treatment protocols.
Previous research has focused on revealing the functions of each individual gene and/or pathway in idiopathic dilated cardiomyopathy (DCM) or ischemic cardiomyopathy (IC). However, the common or specific pathways of the initiation and processes of DCM and IC are still unclear. Here, we attempted to uncover the critical genes and potential molecular networks that play important roles in DCM and ...
AIMS Mutations in the lamin A/C gene (LMNA) have been reported to be involved in dilated cardiomyopathy (DCM) associated with conduction system disease and/or skeletal myopathy. The aim of this study was to perform a mutational analysis of LMNA in a large white population of patients affected by dilated cardiomyopathy with or without associated symptoms. METHODS We performed screening of the ...
BACKGROUND The pathogenesis of diabetic cardiomyopathy (DCM) involves the enhanced activation of peroxisome proliferator activating receptor (PPAR) transcription factors, including the most prominent isoform in the heart, PPARα. In cancer cells and adipocytes, post-translational modification of PPARs have been identified, including ligand-dependent degradation of PPARs by specific ubiquitin lig...
Dilated cardiomyopathy (DCM) is the most common form of primary myocardial disorder and is associated with substantial morbidity and mortality. Increasing evidence suggests that genetic risk factors play an important role in the pathogenesis of idiopathic DCM. However, DCM is a genetically heterogeneous disease, and the genetic defects responsible for DCM in an overwhelming majority of cases re...
AIM Numerous genes are known to cause dilated cardiomyopathy (DCM). However, until now technological limitations have hindered elucidation of the contribution of all clinically relevant disease genes to DCM phenotypes in larger cohorts. We now utilized next-generation sequencing to overcome these limitations and screened all DCM disease genes in a large cohort. METHODS AND RESULTS In this mul...
Objectives: The objective of this study was to investigate effects of immunoadsorption (IA) on methylglyoxal (MG) levels in patients with chronic non-familial dilated cardiomyopathy (DCM), as well as clinical and humoral markers of heart failure. Background: Previous studies have demonstrated favourable outcomes of IA in DCM patients with diabetes mellitus (DM) and that MG sensitizes cultured c...
In diabetic patients, left ventricular (LV) remodeling is highly prevalent; however, little is known about the impact of diabetes on right ventricular (RV) structure and function. We recently found that overexpression of angiotensin (ANG)-converting enzyme 2 (ACE2), which metabolizes ANG-II to ANG-(1-7) and ANG-I to ANG-(1-9), may improve LV remodeling in diabetic cardiomyopathy (DCM). Here, we...
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