BACKGROUND The objective of this review is to evaluate the use of electrical stimulation to treat diabetic neuropathy. Application of electrical stimulation may provide a novel treatment option for large and small fiber neuropathy in persons with diabetes. Large and small nerve neuropathy alters pain, proprioception, touch perception, and motor function, which cause burning foot pain and serve ...

In a recent study, Wattanathorn et al. identified that the combined extract of purple waxy corn and ginger was effective in improving functional and structural changes in STZ-diabetic rats submitted to chronic constriction of the sciatic nerve, an effect that is potentially mediated by the antiox-idant properties of these combined extracts. Although the results have been quite interesting, we w...

The neurotransmitter serotonin (5-hydroxytryptamine, 5-HT) is involved in numerous physiological functions and plays a key role pain modulation including neuropathic pain. Diabetic neuropathy common complication of diabetes mellitus often accompanied by chronic Animal models offer relevant tools for studying the pathophysiological mechanisms pharmacological sensitivity diabetic identifying new ...

BACKGROUND To study the effects of an aqueous extract of date fruit (Phoenix dactylifera L. Arecaceae) diet on diabetic polyneuropathy (DPN) in streptozotocin- (STZ-) induced diabetic rats. METHODS The effects of a date fruit extract (DFE) diet on diabetic neuropathy in STZ-induced diabetic rats were evaluated and compared with a nondiabetic control group, diabetic control group (sham), and v...

Type 2 Diabetes mellitus is a disease which manifests with a variety of cardiovascular risk factors, including hypertension, dyslipidemia and overweight or obesity that contributes to development of long term complications termed diabetic related ailments. Diabetic peripheral neuropathy (DPN) is a debilitating condition affecting as many as one half of all patients with diabetes during the cour...

iii Acknowledgements v List of Figures xiii Chapter One: Introduction 1 1. Diabetes Mellitus 2 2. Diabetic Neuropathy 3 3. Dyslipidemia and Lifestyle Factors 6 4. Mitochondrial Dysfunction 12 5. Inflammation 15 6. Peripheral Nervous System Insulin Resistance 19 7. Exercise Intervention as a Preventative and Treatment for Diabetic Neuropathy 21 8. Study Significance 24 Chapter Two: Phenotypic Ch...

BACKGROUND Between 1992 and 2001 the UK general practice incidence of post-herpetic neuralgia and trigeminal neuralgia declined, whilst the incidence of painful diabetic neuropathy increased. The most common first line treatments were compound analgesics. As therapeutic options have subsequently changed, this study presents updated data on incidence and prescribing patterns in neuropathic pain....

Background: Heightened expression of the receptor for advanced glycation end products (RAGE) contributes to development of systemic diabetic complications, but its contribution to diabetic neuropathy is uncertain. Objective: We studied experimental diabetic neuropathy and its relationship with RAGE expression using streptozotocin (STZ) diabetic mice including a RAGE cohort exposed to long-term ...

The present study evaluated the effectiveness of micronized palmitoylethanolamide (PEA-m) treatment in reducing the painful symptoms experienced by diabetic patients with peripheral neuropathy. PEA-m, a fatty acid amide of the N-acylethanolamine family, was administered (300 mg twice daily) to 30 diabetic patients suffering from painful diabetic neuropathy. Before treatment start, after 30 and ...