The clinical practice of hyperthermic intraperitoneal chemoperfusion (HIPEC) for carcinomatosis has lacked preclinical justification. A standardized mouse model was created to evaluate the independent effects of intraperitoneal chemotherapy. Diffuse colorectal carcinomatosis was generated in mice prior to intraperitoneal lavage with mitomycin C (MMC) at clinically comparable dosing for variable...

A 14 years old boy who had a ventriculo-peritoneal shunt since the age of 5 months, was hospitalized due to headaches, nausea, vomiting and abdominal distension. In abdominal CT and sonographic evaluation, pancreatic pseudocyst or mesentric cyst were suspected. Evaluation of the shunt by radionuclide, however, was diagnostic and revealed a pseudocyst at the peritoneal end of the shunt. Th...

BACKGROUND Free tumour cells in the peritoneal cavity of patients with pancreatic carcinoma carry a poor prognosis. Reactive or degenerative mesothelial cells can make cytological interpretation with conventional stains difficult. Detection of the tumour-associated antigens carcinoembryonic antigen (CEA) and CA19-9 may improve detection. METHODS At staging laparoscopy, 22 patients with pancre...

background: despite a high prevalence of endometriosis, there still exist many challenges in diagnosing the disease. this study aims to evaluate non-invasive and practical diagnostic methods by measuring serum and peritoneal fluid ca 125 levels in patients with endometriosis. a secondary aim is to determine the correlation between these markers with the stage of disease as well as the relations...

The occurrence of peritoneal adhesions in surgical patients is positively correlated with tumor necrosis factor (TNF) levels. In a model of septic peritonitis-cecal ligation and puncture-TNF neutralization prevented formation of peritoneal adhesions and increased mortality, most likely because localization of the septic focus was prevented. To discriminate between the coagulation-independent pr...

BACKGROUND Extrapulmonary tuberculosis has vague symptoms and few signs. It is essential to recognize and diagnose this curable disease prior to performing definitive surgery. Newer tests such as DNA or RNA amplification allow for early diagnosis but have limitations. CASE We report a case of peritoneal tuberculosis in an immigrant woman. She had vague symptoms of low-grade fever, mild abdomi...

The aim of the present study was to investigate the effect of peritoneal lavage with ulinastatin on the expression levels of nuclear factor κB (NF-κB) and tumor necrosis factor (TNF)-α in multiple organs of rats with severe acute pancreatitis (SAP). Male Wistar rats were randomly divided into the following groups: Sham-operated (C), SAP model (SAP), saline lavage (SL), intravenous ulinastatin (...

background in contemporary practice, acute mesenteric ischemia (ami) remains a serious cause of morbidity and mortality in abdominal emergencies. objectives we report the measurement of peritoneal fluid potassium and ph on a small series of rats that developed extensive ami following the surgical ligation of superior mesenteric vessels and compare the results with control groups. materials and ...