Introduction: Most common glioma tumors are tumors of the central nervous system (CNS) which are the cause of about 40 to 50 percent of brain tumors. This type of cancer includes 2 to 3 percent of cancers in the world. Conventional MRI is powerless in the detection and differentiation of benign and malignant tumors. In this case, diffusion weighted imaging (DWI) can create cont...

UNLABELLED Diagnosing childhood tuberculosis requires a strong diagnostic suspicion due to its paucibacillary manifestation. Different scoring systems and algorithms have been developed to deal with such challenge skillfully. These include the Keith Edwards diagnostic score and Stegen's criteria modified by Toledo (Stegen-Toledo). OBJECTIVES To compare the predictive ability of the Keith Edwa...

BACKGROUND Several types of statistical methods are currently available for the meta-analysis of studies on diagnostic test accuracy. One of these methods is the Bivariate Model which involves a simultaneous analysis of the sensitivity and specificity from a set of studies. In this paper, we review the characteristics of the Bivariate Model and demonstrate how it can be extended with a discrete...

Diagnostic testing is essential to distinguish non-diseased individuals from diseased individuals. The sensitivity and specificity are two important indices for the diagnostic accuracy of continuous-scale diagnostic tests. If we want to compare the effectiveness of two tests, it is of interest to construct a confidence interval for the difference of the two sensitivities at a fixed level of spe...

this study was done in research institute of nuclear medicine from 1988-1992 for evaluation of the value of serum thyroglobulin level in comparison with 1-131 whole body scan (1-131 wbs) in patients with differentiated thyroid carcinoma. 204 patients who had total or near total thyroidectomy treated with 1-131 were evaluated in this study. out of 204 patients 136 did not have regional or distan...

background:the diagnostic accuracy of frozen section as an important source of information in surgical pathology is important not only in the management of surgical patients but also as a measure of quality control in surgical pathology. in this study, we evaluated the diagnostic accuracy of frozen sections over a 6-year period in a teaching hospital in iran. methods: we retrospectively review...

BACKGROUND Accurate diagnosis by clinicians is the cornerstone of decision making for recommending clinical interventions. The current best evidence from research concerning diagnostic tests changes unpredictably as science advances. Both clinicians and researchers need dependable access to published evidence concerning diagnostic accuracy. Bibliographic databases such as EMBASE provide the mos...

OBJECTIVES The International Consensus Diagnostic Criteria (ICDC) designed to diagnosis autoimmune pancreatitis (AIP) has been proposed recently. The diagnostic performance of ICDC has not been previously evaluated in diffuse-type and focal-type AIP, respectively, in comparison with the revised HISORt and Asian criteria in Taiwan. DESIGN Prospective, consecutive patient cohort. SETTING Larg...

A long-standing goal of computational protein design is to create proteins similar to those found in Nature. One motivation is to harness the exquisite functional capabilities of proteins for our own purposes. The extent of similarity between designed and natural proteins also reports on how faithfully our models represent the selective pressures that determine protein sequences. As the field o...