A decade after the first studies were performed it is justifiable to claim that molecular techniques have revolutionised the work of the clinical virology laboratory. Hitherto, the role of the virology laboratory was often a retrospective diagnosis based on virus isolation and serology. Nevertheless, the epidemiological data collected in this way justified the continued activity of clinical vir...

L.-J.C. Wong (ed.), Next Generation Sequencing: Translation to Clinical Diagnostics, DOI 10.1007/978-1-4614-7001-4_2, © Springer Science+Business Media New York 2013 Abstract The identifi cation and characterization of the genetic basis of disease is often fundamental to diagnosis. Detection of pathogenic mutations in a DNA sample can lead to a diagnosis, possible prognosis, and prospective the...

The principles of magnetic separation aided by antibodies or other specific binding molecules have been used for isolation of specific viable whole organisms, antigens, or nucleic acids. Whereas growth on selective media may be helpful in isolation of a certain bacterial species, immunomagnetic separation (IMS) technology can isolate strains possessing specific and characteristic surface antige...

Intelligent instruction of fault diagnosis, or troubleshooting, tasks requires the capability to automatically infer the significance of particular test outcomes observed by the learner in a practice environment. This single process is central to virtually every aspect of intelligent instruction in this domain, ranging from evaluating learner proficiency to recommending an effective testing str...

Current IASP diagnostic criteria for CRPS have low specificity, potentially leading to overdiagnosis. This validation study compared current IASP diagnostic criteria for CRPS to proposed new diagnostic criteria (the "Budapest Criteria") regarding diagnostic accuracy. Structured evaluations of CRPS-related signs and symptoms were conducted in 113 CRPS-I and 47 non-CRPS neuropathic pain patients....

Traumatic brain injury (TBI) remains a serious medical issue worldwide, because of its high prevalence, temporary disability and mortality rate. TBI is more common in young middle-aged, i.e. the most active labor market, social relations part population. damage to from an external mechanical force, leading or permanent impairments cognitive, physical, psychosocial functions, with altered state ...

Previous works have pointed out the crucial need for comparison between knowledge diagnostic tools in the field of Intelligent Tutoring Systems (ITS). In this paper, we present an approach to compare knowledge diagnostics. We illustrate our proposition by applying three criteria of comparison for various diagnostic tools in geometry. K eywords: knowledge diagnostic, student modeling, comparison...

With increasing innovations aimed at the treatment of chronic liver disease (CLD), the precise staging of liver fibrosis is important to help establish efficacious management of disease activity in each patient. The development of biomarkers capable of non-invasive staging of fibrosis in the liver is challenging as fibrogenesis is a part of the normal wound healing response. There is an array o...

Ther term cervicogenic headache (CEH) was introduced by Sjaastad and co-workers in 1983. In 1990 Sjaastad et al. published diagnostic criteria for CEH. In 1998 refinements of these criteria were published, emphasising the use of diagnostic nerve blocks in patients with CEH as important confirmatory evidence. However, the standardisation of diagnostic nerve blocks in the diagnosis of CEH remains...