The study was aimed at developing extended release matrix tablets of poorly water-soluble diclofenac sodium and highly water-soluble metformin hydrochloride by direct compression using cashew gum, xanthan gum and hydroxypropylmethylcellulose (HPMC) as release retardants. The suitability of light grade cashew gum as a direct compression excipient was studied using the SeDeM Diagram Expert System...

In this study, a simple, selective, and accurate analysis method was developed for the simultaneous determination of anti-inflammatory drugs (paracetamol diclofenac) existing inlet outlet wastewater treatment system. This used solid-phase extraction (SPE) reversed-phase high-performance liquid chromatography with photodiode array detector (HPLC-PDA). Separation performed using an HSR C18 column...

BACKGROUND A new propylene glycol-free and reduced-volume formulation of diclofenac sodium 75 mg/mL designed for intradeltoid administration has been found to be bioequivalent to a reference formulation of diclofenac sodium 75 mg/3 mL given via the intragluteal route in normal healthy volunteers. Standard needles may not reach the gluteus maximus muscle in many cases, especially in the obese. T...

OBJECTIVE To evaluate the preemptive effects of diclofenac sodium, in combination with remifentanil and ketamine. METHODS A prospective, randomized, double blind, placebo-controlled trial was carried out at the Hacettepe University Hospital, Ankara, Turkey from September to December 2004. Forty-three, American Society of Anesthesiology physical status group I-II women, aged >18 years, who wou...

acid, is a non-steroidal anti-flammatory drug. The structures of two monoclinic forms of diclofenac acid with space groups of P21/c (HD1) and C2/c (HD2) were reported by Castellari and Ottani.1 In this paper, we report on a new orthorhombic form of diclofenac acid (HD3) with the space group Pcan. Diclofenac sodium, a sodium salt of 2-[(2,6dichlorophenyl)amino]benzeneacetic acid (2 g) was dissol...

Meloxicam is a non-steroidal anti inflammatory drug (NSAIDs). It has been reported as a safe substitute of diclofenac sodium which has been banned for veterinary use in Pakistan, Nepal and India due to its relay toxicity associated with the catastrophic and unprecedented decline in vulture population during last 17 years. Diclofenac was very cheap and commonly used drug and it was highly toxic ...