PURPOSE 1,1-Bis(3'-indolyl)-1-(p-substitutedphenyl)methanes [methylene-substituted diindolylmethanes (C-DIM)] containing p-trifluoromethyl, p-t-butyl, and p-phenyl substituents activate peroxisome proliferator-activated receptor gamma (PPARgamma) and inhibit growth of several different cancer cell lines through receptor-dependent and receptor-independent pathways. The purpose of this study is t...

3,3¶-Diindolylmethane (DIM) is a stable condensation product of indole-3-carbanol, a potential breast cancer chemoprevention agent. Human breast cancer cell lines were studied to better understand its mechanisms. In vitro experiments were done in MCF-7, T47D, BT-20 and BT-474 cells using MTT, ELISA, immunoblotting assays, reverse transcription-PCR, protein half-life, confocal microscopy, cell f...

This study compares the sonographic and CT findings in a group of infants with macrocrania and correlates those findings with neurologic outcome to determine the diagnostic accuracy and prognostic value of sonography. Sonographic findings in 255 infants with macrocrania are described. Of the 195 term infants examined, 130 had normal sonograms, 11 (5.6%) had significant abnormalities, and 54 had...

The levels of milk-specific mRNAs (a-casein, whey acidic protein) and proteins (casein, a-lactalbumin) were examined in the DIM series of mammary preneoplastic outgrowth lines and tumors. The constitutive production of casein protein was variable among the preneoplastic DIM outgrowth lines maintained in virgin mice. Outgrowth line DIM-2 con sistently expressed a very low level of casein mRNA an...

We prove the following three closely related results: (1) Every finite simple group G has a profinite presentation with 2 generators and at most 18 relations. (2) If G is a finite simple group, F a field and M is an FG-module, then dim H.G;M/ .17:5/ dim M . (3) If G is a finite group, F a field and M is an irreducible faithful FG-module, then dim H.G;M/ .18:5/ dim M . Mathematics Subject Classi...

This paper investigates the behavior of the Hausdorr dimensions of the limit sets n and of a sequence of Kleinian groups ? n ! ?, where M = H 3 =? is geometrically nite. We show if ? n ! ? strongly, then: (a) M n = H 3 =? n is geometrically nite for all n 0, (b) n ! in the Hausdorr topology, and (c) H: dim((n) ! H: dim((), if H: dim(() 1. On the other hand, we give examples showing the dimensio...